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. 2024 Apr 2;4(2):e051.
doi: 10.1097/ONO.0000000000000051. eCollection 2024 Jun.

Increased Incidence of Vestibular Disorders in Patients With SARS-CoV-2

Lawrance Lee  1 , Evan French  2 , Daniel H Coelho  1 , Nauman F Manzoor  1 ; N3C consortium.; Adam B Wilcox  1   2 , Adam M Lee  1   2 , Alexis Graves  1   2 , Alfred Anzalone  1   2 , Amin Manna  1   2 , Amit Saha  1   2 , Amy Olex  1   2 , Andrea Zhou  1   2 , Andrew E Williams  1   2 , Andrew Southerland  1   2 , Andrew T Girvin  1   2 , Anita Walden  1   2 , Anjali A Sharathkumar  1   2 , Benjamin Amor  1   2 , Benjamin Bates  1   2 , Brian Hendricks  1   2 , Brijesh Patel  1   2 , Caleb Alexander  1   2 , Carolyn Bramante  1   2 , Cavin Ward-Caviness  1   2 , Charisse Madlock-Brown  1   2 , Christine Suver  1   2 , Christopher Chute  1   2 , Christopher Dillon  1   2 , Chunlei Wu  1   2 , Clare Schmitt  1   2 , Cliff Takemoto  1   2 , Dan Housman  1   2 , Davera Gabriel  1   2 , David A Eichmann  1   2 , Diego Mazzotti  1   2 , Don Brown  1   2 , Eilis Boudreau  1   2 , Elaine Hill  1   2 , Elizabeth Zampino  1   2 , Emily Carlson Marti  1   2 , Emily R Pfaff  1   2 , Evan French  1   2 , Farrukh M Koraishy  1   2 , Federico Mariona  1   2 , Fred Prior  1   2 , George Sokos  1   2 , Greg Martin  1   2 , Harold Lehmann  1   2 , Heidi Spratt  1   2 , Hemalkumar Mehta  1   2 , Hongfang Liu  1   2 , Hythem Sidky  1   2 , J W Awori Hayanga  1   2 , Jami Pincavitch  1   2 , Jaylyn Clark  1   2 , Jeremy Richard Harper  1   2 , Jessica Islam  1   2 , Jin Ge  1   2 , Joel Gagnier  1   2 , Joel H Saltz  1   2 , Joel Saltz  1   2 , Johanna Loomba  1   2 , John Buse  1   2 , Jomol Mathew  1   2 , Joni L Rutter  1   2 , Julie A McMurry  1   2 , Justin Guinney  1   2 , Justin Starren  1   2 , Karen Crowley  1   2 , Katie Rebecca Bradwell  1   2 , Kellie M Walters  1   2 , Ken Wilkins  1   2 , Kenneth R Gersing  1   2 , Kenrick Dwain Cato  1   2 , Kimberly Murray  1   2 , Kristin Kostka  1   2 , Lavance Northington  1   2 , Lee Allan Pyles  1   2 , Leonie Misquitta  1   2 , Lesley Cottrell  1   2 , Lili Portilla  1   2 , Mariam Deacy  1   2 , Mark M Bissell  1   2 , Marshall Clark  1   2 , Mary Emmett  1   2 , Mary Morrison Saltz  1   2 , Matvey B Palchuk  1   2 , Melissa A Haendel  1   2 , Meredith Adams  1   2 , Meredith Temple-O'Connor  1   2 , Michael G Kurilla  1   2 , Michele Morris  1   2 , Nabeel Qureshi  1   2 , Nasia Safdar  1   2 , Nicole Garbarini  1   2 , Noha Sharafeldin  1   2 , Ofer Sadan  1   2 , Patricia A Francis  1   2 , Penny Wung Burgoon  1   2 , Peter Robinson  1   2 , Philip R O Payne  1   2 , Rafael Fuentes  1   2 , Randeep Jawa  1   2 , Rebecca Erwin-Cohen  1   2 , Rena Patel  1   2 , Richard A Moffitt  1   2 , Richard L Zhu  1   2 , Rishi Kamaleswaran  1   2 , Robert Hurley  1   2 , Robert T Miller  1   2 , Saiju Pyarajan  1   2 , Sam G Michael  1   2 , Samuel Bozzette  1   2 , Sandeep Mallipattu  1   2 , Satyanarayana Vedula  1   2 , Scott Chapman  1   2 , Shawn T O'Neil  1   2 , Soko Setoguchi  1   2 , Stephanie S Hong  1   2 , Steve Johnson  1   2 , Tellen D Bennett  1   2 , Tiffany Callahan  1   2 , Umit Topaloglu  1   2 , Usman Sheikh  1   2 , Valery Gordon  1   2 , Vignesh Subbian  1   2 , Warren A Kibbe  1   2 , Wenndy Hernandez  1   2 , Will Beasley  1   2 , Will Cooper  1   2 , William Hillegass  1   2 , Xiaohan Tanner Zhang  1   2
Affiliations

Increased Incidence of Vestibular Disorders in Patients With SARS-CoV-2

Lawrance Lee et al. Otol Neurotol Open. .

Abstract

Objective: Determine the incidence of vestibular disorders in patients with SARS-CoV-2 compared to the control population.

Study design: Retrospective.

Setting: Clinical data in the National COVID Cohort Collaborative database (N3C).

Methods: Deidentified patient data from the National COVID Cohort Collaborative database (N3C) were queried based on variant peak prevalence (untyped, alpha, delta, omicron 21K, and omicron 23A) from covariants.org to retrospectively analyze the incidence of vestibular disorders in patients with SARS-CoV-2 compared to control population, consisting of patients without documented evidence of COVID infection during the same period.

Results: Patients testing positive for COVID-19 were significantly more likely to have a vestibular disorder compared to the control population. Compared to control patients, the odds ratio of vestibular disorders was significantly elevated in patients with untyped (odds ratio [OR], 2.39; confidence intervals [CI], 2.29-2.50; P < 0.001), alpha (OR, 3.63; CI, 3.48-3.78; P < 0.001), delta (OR, 3.03; CI, 2.94-3.12; P < 0.001), omicron 21K variant (OR, 2.97; CI, 2.90-3.04; P < 0.001), and omicron 23A variant (OR, 8.80; CI, 8.35-9.27; P < 0.001).

Conclusions: The incidence of vestibular disorders differed between COVID-19 variants and was significantly elevated in COVID-19-positive patients compared to the control population. These findings have implications for patient counseling and further research is needed to discern the long-term effects of these findings.

Keywords: COVID-19; Dizziness; SARS-CoV-2; Vestibular disorder.

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Conflict of interest statement

None declared.

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