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. 2024 Jun 17;13(2):47.
doi: 10.3390/antib13020047.

Elevated Immunoglobulin E Serum Levels: Possible Underlying Factors That Can Cause an Inborn Error of Immunity in the Pediatric Population with Recurrent Infections

Sînziana Oprițescu  1 , Gabriela Viorela Nițescu  2   3 , Daniela Cîrnațu  4 , Svetlana Trifunschi  4 , Melania Munteanu  4 , Mihaela Golumbeanu  3 , Dora Boghițoiu  2   3 , Adriana Maria Dărăban  5 , Elena Iuliana Ilie  6 , Elena Moroșan  1
Affiliations

Elevated Immunoglobulin E Serum Levels: Possible Underlying Factors That Can Cause an Inborn Error of Immunity in the Pediatric Population with Recurrent Infections

Sînziana Oprițescu et al. Antibodies (Basel). .

Abstract

Elevated immunoglobulin E (IgE) levels are commonly associated with allergies. However, high IgE levels are also found in several other infectious and non-infectious disorders. Elevated IgE levels typically suggest allergies, eczema, or recurrent skin infections. Hyperimmunoglobulin E (hyper-IgE) levels typically reflect a monogenic atopic condition or inborn immune defects with an atopic phenotype. The aim of our research is to investigate and observe the clinical characteristics of children with increased IgE levels who have previously manifested infectious diseases. Furthermore, the retrospective study considers other factors, such as demographic characteristics (sex, area/environment, and age), and their effect on IgE serum levels. To answer this question, we conducted a one-year hospital-based retrospective study that included 200 hospitalized children who had at least two viral or bacterial infections in the six months preceding hospitalization. Measurements of IgE and allergen panels (respiratory and digestive) using blood samples revealed that individuals who tested positive for the body's synthesis of hyper-IgE were not observably allergic to any potential allergens despite having higher total serum IgE. According to the results, there was a strong correlation between elevated IgE serum levels and a history of infectious diseases among the patients.

Keywords: HIES; clinical manifestation; hyper-IgE; infectious diseases.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
The presence of increased IgE according to the age category.
Figure 2
Figure 2
The presence of increased IgE according to the environment.
Figure 3
Figure 3
A graphic representation of the allergen panel results for patients identified as having elevated total serum IgE levels.
Figure 4
Figure 4
The graphic representation of the PCA test results for possible correlations.
Figure 5
Figure 5
ROC curves obtained from the IgE serum levels. Sensitivity is shown in the ordinate, while the false positive rate (1-specificity) is presented in the abscissa.
See this image and copyright information in PMC

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