Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jul 23;332(4):335-337.
doi: 10.1001/jama.2024.9997.

Prostate-Specific Antigen Values in Transgender Women Receiving Estrogen

Affiliations

Prostate-Specific Antigen Values in Transgender Women Receiving Estrogen

Farnoosh Nik-Ahd et al. JAMA. .
No abstract available

Plain language summary

This study examines prostate-specific antigen values among transgender women in the Veterans Health Administration receiving estrogen.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest Disclosures: Dr Cooperberg reported receiving personal fees from Janssen, AstraZeneca, Astellas, Pfizer, Bayer, Verana Health, Veracyte, Lynx Dx, ExoDx, and Merck outside the submitted work. No other disclosures were reported.

Figures

Figure.
Figure.. Violin Plots of Prostate-Specific Antigen (PSA) Obtained per Patient
A, All PSAs obtained (N = 852) in 210 patients meeting inclusion criteria. B, First PSA per patient regardless of age. C, Median of all PSAs per patient. The rectangular shaded area on each plot represents the IQR and the white dot represents the median. Distribution of PSA values in transgender women receiving gender-affirming hormones is based on PSAs after estrogen use for at least 6 consecutive months.

Comment in

References

    1. Nik-Ahd F, De Hoedt A, Butler C, et al. . Prostate cancer in transgender women in the Veterans Affairs Health System, 2000-2022. JAMA. 2023;329(21):1877-1879. doi:10.1001/jama.2023.6028 - DOI - PMC - PubMed
    1. Yousef GM, Diamandis EP. The new human tissue kallikrein gene family: structure, function, and association to disease. Endocr Rev. 2001;22(2):184-204. doi:10.1210/edrv.22.2.0424 - DOI - PubMed
    1. Nik-Ahd F, Waller J, De Hoedt AM, et al. . Seeing the unseen: how can we best identify transgender women within the Veterans Affairs healthcare system’s electronic medical record? J Sex Med. 2023;20(4):559-567. doi:10.1093/jsxmed/qdac033 - DOI - PubMed
    1. Capitanio U, Perrotte P, Zini L, et al. . Population-based analysis of normal total PSA and percentage of free/total PSA values: results from screening cohort. Urology. 2009;73(6):1323-1327. doi:10.1016/j.urology.2008.10.026 - DOI - PubMed
    1. Washington DL. National Veteran Health Equity Report 2021. Focus on Veterans Health Administration patient experience and health care quality. Published September 2022. Accessed March 4, 2024. https://www.va.gov/HEALTHEQUITY/docs/NVHER_2021_Report_508_Conformant.pdf

Publication types