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Randomized Controlled Trial
. 2024 Aug;79(2):371-381.
doi: 10.1002/jpn3.12294. Epub 2024 Jun 24.

Growth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy

Valeria De Toro  1 , Gigliola Alberti  1 , Angelica Dominguez  2 , Karina Carrasco-Negüe  3 , Pedro Ferrer  4 , Rodrigo Valenzuela  4 , Maria Luisa Garmendia  5 , Paola Casanello  3   6
Affiliations
Randomized Controlled Trial

Growth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy

Valeria De Toro et al. J Pediatr Gastroenterol Nutr. 2024 Aug.

Abstract

Background: Previous studies of maternal docosahexaenoic acid (DHA) supplementation during pregnancy have controversial and contrasting results on the short and long-term effects on early child growth. The impact of this nutritional intervention on the postnatal growth patterns in the offspring of women with pregestational overweight/obesity (PGO) also remains controversial.

Objective: To analyze the postnatal growth patterns during the first 4 months of life in the offspring of women with PGO randomly supplemented with 800 mg/day (PGO-800) compared with normative doses of 200 mg/day (PGO-200) of DHA during pregnancy (<15 weeks of gestation until delivery).

Methods: This study evaluated the growth patterns during the first 4 months of life of 169 infants of the women that participated in the MIGHT study (NCT02574767). We included the infants of women from the PGO-200 (n = 81) and PGO-800 group (n = 88). The growth patterns (weight, length, and head circumference) and change in z-score (World health Organization charts) were evaluated.

Results: Throughout the first 4 months of life, the infants of the PGO-800 group had lower weight-for-length z-score (coef. -0.65, 95% confidence interval [CI] -1.07, -0.22, p = 0.003) and lower body mass index-for-age z-score (coef. -0.56, 95% CI -0.99, -0.12, p = 0.012) compared with the PGO-200 group adjusted by maternal body mass index, gestational weight gain, gestational age, insulin in cord blood and infant feeding (exclusive breastfed, not breastfed, and partially breastfed).

Conclusions: Maternal supplementation with DHA during pregnancy could beneficially limit the offspring's postnatal weight gain during the first 4 months of life.

Keywords: DHA supplementation; childhood obesity; maternal obesity.

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References

REFERENCES

    1. World Health Organization. Obesity and overweight: fact sheet. Updated June 2021. Accessed October 15, 2023. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight
    1. Ogden CL, Carroll MD, Lawman HG, et al. Trends in obesity prevalence among children and adolescents in the United States, 1988‐1994 through 2013‐2014. JAMA. 2016;315:2292‐2299.
    1. Gillman MW. Interrupting intergenerational cycles of maternal obesity. Nestlé Nutr Inst Work Ser. 2016;85:59‐69.
    1. Voerman E, Santos S, Patro Golab B, et al. Maternal body mass index, gestational weight gain, and the risk of overweight and obesity across childhood: an individual participant data meta‐analysis. PLoS Med. 2019;16:e1002744.
    1. Linares J, Corvalán C, Galleguillos B, et al. The effects of pre‐pregnancy BMI and maternal factors on the timing of adiposity rebound in offspring. Obesity. 2016;24:1313‐1319.

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