Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Aug;48(8):1912-1920.
doi: 10.1002/wjs.12264. Epub 2024 Jun 24.

Preoperative osteopenia is associated with prognosis in patients after resection of esophageal cancer

Takehiro Kagaya  1 , Atsushi Miki  1 , Jun Watanabe  1 , Rihito Kanamaru  1 , Shiro Matsumoto  1 , Kentaro Kurashina  1 , Shin Saito  1 , Takumi Teratani  1 , Yoshinori Hosoya  1 , Yasunaru Sakuma  1 , Joji Kitayama  1 , Naohiro Sata  1
Affiliations

Preoperative osteopenia is associated with prognosis in patients after resection of esophageal cancer

Takehiro Kagaya et al. World J Surg. 2024 Aug.

Abstract

Background: Osteopenia reflects frailty and has been shown to be associated with outcomes in cancer patients. This study was undertaken to examine whether osteopenia is an independent prognostic factor in patients with esophageal cancer after resection.

Methods: A total of 214 patients who underwent surgery for esophageal cancer were analyzed retrospectively. Bone mineral density (BMD) of the 11th thoracic vertebra was measured by computed tomography scan, and patients classified into osteopenia and normal BMD groups with BMD <160 Hounsfield units as the cutoff. Clinicopathological data and prognosis were analyzed.

Results: The 5-year survival rate was 55.4% for the osteopenia group and 74.7% for the normal BMD group with a significantly worse prognosis in the osteopenia group (p = 0.0080). In multivariable analysis, osteopenia was a significant independent risk factor associated with overall survival (hazard ratio [HR] 1.90, 95% confidence interval [CI] 1.27-3.34, and p = 0.0151) along with R1/2 resection (HR 3.02, 95% CI 1.71-5.18, and p = 0.0002).

Conclusion: In patients with esophageal cancer undergoing resection, osteopenia may be a surrogate marker for frailty and an independent predictor of prognosis.

Keywords: bone mineral density; esophageal cancer; osteopenia; prognosis; survival.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

REFERENCES

    1. Sung, H., J. Ferlay, I. Soerjomataram, M. Laversanne, I. Soerjomataram, A. Jemal, and F. Bray. 2021. “GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.” CA: A Cancer Journal for Clinicians 71(3): 209–249. https://doi.org/10.3322/caac.21660.
    1. Shah, M. A., E. B. Kennedy, D. V. Catenacci, D. C. Deighton, K. A. Goodman, N. K. Malhotra, C. Willett, et al. 2020. “Treatment of Locally Advanced Esophageal Carcinoma: ASCO Guideline.” Journal of Clinical Oncology 38(23): 2677–2694. https://doi.org/10.1200/jco.20.00866.
    1. Cuesta, M. A., N. van der Wielen, J. Straatman, and D. L. van der Peet. 2016. “Video‐assisted Thoracoscopic Esophagectomy: Keynote Lecture.” Gen Thorac Cardiovasc Surg 64(7): 380–385. https://doi.org/10.1007/s11748‐016‐0650‐3.
    1. Kanekiyo, S., S. Takeda, M. Tsutsui, M. Nishiyama, M. Kitahara, Y. Shindo, Y. Tokumitsu, et al. 2018. “Low Invasiveness of Thoracoscopic Esophagectomy in the Prone Position for Esophageal Cancer: A Propensity Score‐Matched Comparison of Operative Approaches between Thoracoscopic and Open Esophagectomy.” Surgical Endoscopy 32(4): 1945–1953. https://doi.org/10.1007/s00464‐017‐5888‐z.
    1. Mariette, C., S. R. Markar, T. S. Dabakuyo‐Yonli, B. Meunier, D. Pezet, D. Collet, X. B. D’Journo, et al. 2019. “Hybrid Minimally Invasive Esophagectomy for Esophageal Cancer.” New England Journal of Medicine 380(2): 152–162. https://doi.org/10.1056/nejmoa1805101.

LinkOut - more resources