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. 2024 Oct;30(7):4126-4144.
doi: 10.1111/odi.15046. Epub 2024 Jun 24.

Efficacy of topical agents in oral mucositis prevention: Systematic review and network meta-analysis

Martina Coppini  1   2 , Vito Carlo Alberto Caponio  3 , Rodolfo Mauceri  1   4 , Maria Eleonora Bizzoca  3 , Luigi Laino  5 , Alejandro I Lorenzo-Pouso  6 , Diana Russo  5 , Giuseppe Troiano  3 , Fábio França Vieira E Silva  6   7 , Lorenzo Lo Muzio  3 , Giuseppina Campisi  4
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Efficacy of topical agents in oral mucositis prevention: Systematic review and network meta-analysis

Martina Coppini et al. Oral Dis. 2024 Oct.

Abstract

Background: Oral mucositis (OM) is considered one of the most common side effects of patients undergoing cancer therapy. OM prevention plays a crucial role in the effectiveness of cancer treatment and the patient's quality of life. Different preventive treatments have been proposed in clinical trials, however with inconclusive results.

Materials and methods: A systematic review search was conducted in PubMed, Scopus, Web of Science, and Cochrane Database to answer the PICO question: in cancer patients, do specific topical agents compared to standard treatments or placebo reduce the onset and severity of oral mucositis? The risk of bias was assessed, and a network meta-analysis was conducted.

Results: Of 2913 results, 30 randomized clinical trials were considered suitable for inclusion. A total of 2564 patients were analyzed, of which 1284 belonged to the test group and 1280 belonged to the control group. Natural products were the most used, followed mainly by antimicrobial agents, coating agents, and basic oral care measures. Topical sucralfate resulted in the most powerful intervention for the OM prevention (OR = 0.04, 95%C.I. = 0.01-0.25, p-value = 0.001).

Conclusion: Due to its cytoprotective action, low cost, ease of administration, and safety, sucralfate could become a potential ally to prevent the onset of OM during cancer therapy.

Keywords: cancer; network meta‐analysis; oral mucosa; oral mucositis; prevention; stomatitis; sucralfate; systematic review; therapy.

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REFERENCES

    1. Adamietz, I. A., Rahn, R., Böttcher, H. D., Schäfer, V., Reimer, K., & Fleischer, W. (1998). Prophylaxis with povidone‐iodine against induction of oral mucositis by radiochemotherapy. Supportive Care in Cancer, 6, 373–377.
    1. Ala, S., Saeedi, M., Janbabai, G., Ganji, R., Azhdari, E., & Shiva, A. (2016). Efficacy of Sucralfate mouth wash in prevention of 5‐fluorouracil induced Oral Mucositis: A prospective, randomized, double‐blind, controlled trial. Nutrition and Cancer, 68, 456–463.
    1. Allison, R. R., Ambrad, A. A., Arshoun, Y., Carmel, R. J., Ciuba, D. F., Feldman, E., Finkelstein, S. E., Gandhavadi, R., Heron, D. E., Lane, S. C., Longo, J. M., Meakin, C., Papadopoulos, D., Pruitt, D. E., Steinbrenner, L. M., Taylor, M. A., Wisbeck, W. M., Yuh, G. E., Nowotnik, D. P., & Sonis, S. T. (2014). Multi‐institutional, randomized, double‐blind, placebo‐controlled trial to assess the efficacy of a mucoadhesive hydrogel (MuGard) in mitigating oral mucositis symptoms in patients being treated with chemoradiation therapy for cancers of the head and neck. Cancer, 120, 1433–1440.
    1. Antonacci, D., Caponio, V. C. A., Troiano, G., Pompeo, M. G., Gianfreda, F., & Canullo, L. (2023). Facial scanning technologies in the era of digital workflow: A systematic review and network meta‐analysis. Journal of Prosthodontic Research, 67, 321–336.
    1. Ariyawardana, A., Cheng, K. K. F., Kandwal, A., Tilly, V., Al‐Azri, A. R., Galiti, D., Chiang, K., Vaddi, A., Ranna, V., Nicolatou‐Galitis, O., Lalla, R. V., Bossi, P., Elad, S., & Mucositis Study Group of the Multinational Association of Supportive Care in Cancer/International Society for Oral O. (2019). Systematic review of anti‐inflammatory agents for the management of oral mucositis in cancer patients and clinical practice guidelines. Supportive Care in Cancer, 27, 3985–3995.

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