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. 1985 Mar;33(3):155-61.

[Pregnancies by fertilization in vitro. Biochemistry of the follicular fluid]

[Article in French]
P Cristol, A Chabab, F Diafouka, O Flandre, N Bressot, A M Cristol, B Hedon, F Deschamps, M T Gelis
  • PMID: 3892441

[Pregnancies by fertilization in vitro. Biochemistry of the follicular fluid]

[Article in French]
P Cristol et al. Pathol Biol (Paris). 1985 Mar.

Abstract

Fifty four follicular fluids containing 41 oocytes were sampled from 6 patients in which at least one pregnancy was obtained after IVF. Their biochemical composition has been correlated with the follicle maturity and oocyte quality. Three components have been assayed: steroids, prostanoids, proteolytic enzymes. Determinations of estrogens and total aromatisable androgens were carried out by the enzymatic technic of Nicolas and al.; progesterone and 17 OH progesterone by RIA. Development of in vitro cultured and fertilized oocytes appears to be improved when progesterone and estrogens concentrations in the follicular fluid are above 2 000 and 600 ng/ml respectively, with an A/E ratio under 1. On the other hand, prostanoids (T X B2, PGE2, PGF2 alpha determined by RIA) and proteolytic enzymes : (collagenolytic and kallikrein type activities) seemed related to ovulatory activity rather than to oocyte quality.

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