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. 2024 Nov 27;39(12):1942-1944.
doi: 10.1093/ndt/gfae149.

Torque Teno Virus-guided monitoring of immunosuppressive therapy

Sebastian Kapps  1 , Frederik Haupenthal  1 , Gregor Bond  1
Affiliations

Torque Teno Virus-guided monitoring of immunosuppressive therapy

Sebastian Kapps et al. Nephrol Dial Transplant. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

G.B. received a fee for a talk at a scientific conference and the preparation of communication material on the TTV-RGENE PCR from bioMérieux.

Figures

Figure 1:
Figure 1:
Illustration of the role of TTV as an immunometer. On the left side of the scale, high levels of immunosuppression are indicated, shown by an elevated TTV load in the patient's blood, which correlate with a higher risk of infections in kidney transplant patients. Conversely, the right side depicts insufficient immunosuppression, characterized by low TTV load, resulting in a higher risk of organ rejection. The optimal balance is in the centre, where immunosuppression is well-regulated, and TTV load is in an optimal range. Additionally, the figure references various fields where TTV load might be indicative: CAR-T-cell therapy response and ICANS risk in bone marrow transplantation, DMARD response in autoimmune diseases, ICU admission risk due to COVID-19 and seroconversion after SARS-CoV-2 vaccination. The figure was adapted from the original provided by Manon Zuurmond and Joris Rotmans from the Department of Internal Medicine at the University Leiden, The Netherlands. ICU, intensive care unit.
See this image and copyright information in PMC

References

    1. Jaksch P, Gorzer I, Puchhammer-Stockl E et al. Integrated immunologic monitoring in solid organ transplantation: the road toward Torque Teno Virus-guided immunosuppression. Transplantation 2022;106:1940–51. 10.1097/TP.0000000000004153 - DOI - PMC - PubMed
    1. Gorzer I, Haupenthal F, Maggi F et al. Validation of plasma Torque Teno viral load applying a CE-certified PCR for risk stratification of rejection and infection post kidney transplantation. J Clin Virol 2023;158:105348. 10.1016/j.jcv.2022.105348 - DOI - PubMed
    1. Haupenthal F, Rahn J, Maggi F et al. A multicentre, patient- and assessor-blinded, non-inferiority, randomised and controlled phase II trial to compare standard and torque teno virus-guided immunosuppression in kidney transplant recipients in the first year after transplantation: TTVguideIT . Trials 2023;24:213. 10.1186/s13063-023-07216-0 - DOI - PMC - PubMed
    1. Eskandary F, Bond G, Mohan K. Torque Teno Virus-guided immunosuppression in kidney transplantation: expanding the application. Kidney Int Rep 2024;9:1568–70. 10.1016/j.ekir.2024.04.057 - DOI - PMC - PubMed
    1. Haupenthal F, Bond G. Torque Teno Viral plasma load for immunologic monitoring in solid organ transplantation: one step further. Transplantation 2023;107:e326–7. 10.1097/TP.0000000000004817 - DOI - PMC - PubMed