Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2024 Jun 12;12(6):1299.
doi: 10.3390/biomedicines12061299.

Alcoholic Acute Pancreatitis, a Retrospective Study about Clinical Risk Factors and Outcomes-A Seven-Year Experience of a Large Tertiary Center

Deniz Gűnșahin  1   2 , Andrei Vicențiu Edu  1   3 , Mihai Radu Pahomeanu  1   3 , Tudor Ștefan Mitu  1 , Andreea Irina Ghiță  1 , Anamaria Simona Odorog  1 , Carmen Monica Preda  1   4 , Lucian Negreanu  1   3
Affiliations

Alcoholic Acute Pancreatitis, a Retrospective Study about Clinical Risk Factors and Outcomes-A Seven-Year Experience of a Large Tertiary Center

Deniz Gűnșahin et al. Biomedicines. .

Abstract

(1) Background: Alcohol consumption is one of the main causes of acute pancreatitis. (2) Material and Methods: In this unicentric retrospective cohort study, we selected 1855 patients from the Bucharest Acute Pancreatitis Index (BUC-API) who presented with acute pancreatitis. We investigated correlations between Alcoholic Acute Pancreatitis (AAP) and the rate of complications, cost, length of hospitalization and rate of recurrence. (3) Results: We found a moderately strong association between AAP and recurrence (p < 0.01) and observed that the disease is likelier to evolve with pseudocysts and walled-off necrosis than other forms of AP. Patients with AAP are less likely to have a morphologically normal pancreas than patients suffering from AP of other causes (p < 0.01), but a low probability of requiring intensive care unit admission (p < 0.01) significantly lowers daily cost (Md = 154.7 EUR compared to Md = 204.4 EUR) (p < 0.01). (4) Conclusions: This study's data show that patients with AAP have a greater rate of pseudocyst occurrence, lower intensive care unit admittance rate and lower cost of hospitalization than patients with AP of other causes. Typical Sketch: A middle-aged male tobacco smoker with recurrent AP, lower risk of in-hospital mortality and complications such as pseudocysts; treated in a gastroenterological ward and discharged at-will.

Keywords: ICU; acute pancreatitis; alcohol; cost; outcome; pseudocyst; recurrence; risk factors.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.

Figures

Figure 1
Figure 1
Recurrence related to etiology.
Figure 2
Figure 2
Gender distribution across groups.
Figure 3
Figure 3
Age distribution in the two patient groups.
Figure 4
Figure 4
ICU admittance across groups.
Figure 5
Figure 5
Distribution of morphology across groups.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Polishchuk I., Halperin D., Algedafy A., Delgado J.-S., Zamir M., Zamir D. Epidemiology of Acute Pancreatitis in Southern Israel: A Retrospective Study. Isr. Med. Assoc. J. 2020;22:308–312. - PubMed
    1. Belfrage H., Lankinen E., Kylänpää L., Louhimo J. Acute Pancreatitis in Helsinki in 2016−2018: Incidence, Etiology and risk Factors—Analysis of 1378 acute pancreatitis episodes in a Finnish normal population. Scand. J. Gastroenterol. 2023;58:88–93. doi: 10.1080/00365521.2022.2099760. - DOI - PubMed
    1. Drinking Too Much Alcohol Can Harm Your Health Learn the Facts|CDC. [(accessed on 15 July 2023)]; Available online: https://www.cdc.gov/alcohol/about-alcohol-use/index.html.
    1. Nieto L.M., Salazar M., Kinnucan J., Lukens F.J., Argueta P.P. Incidence, Burden, and Predictors of Readmission for Acute Alcoholic Pancreatitis: A National Analysis over 11 Months. Dig. Dis. Sci. 2023;68:423–433. doi: 10.1007/s10620-022-07798-w. - DOI - PubMed
    1. Yasuda H., Horibe M., Sanui M., Sasaki M., Suzuki N., Sawano H., Goto T., Ikeura T., Takeda T., Oda T., et al. Etiology and mortality in severe acute pancreatitis: A multicenter study in Japan. Pancreatology. 2020;20:307–317. doi: 10.1016/j.pan.2020.03.001. - DOI - PubMed

LinkOut - more resources