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Review
. 2024 May 23;15(6):671.
doi: 10.3390/genes15060671.

Cardiac Remodeling and Ventricular Pacing: From Genes to Mechanics

Onoufrios Malikides  1 , Emmanouel Simantirakis  1   2 , Evangelos Zacharis  1   2 , Konstantinos Fragkiadakis  1   2 , George Kochiadakis  1   2 , Maria Marketou  1   2
Affiliations
Review

Cardiac Remodeling and Ventricular Pacing: From Genes to Mechanics

Onoufrios Malikides et al. Genes (Basel). .

Abstract

Cardiac remodeling and ventricular pacing represent intertwined phenomena with profound implications for cardiovascular health and therapeutic interventions. This review explores the intricate relationship between cardiac remodeling and ventricular pacing, spanning from the molecular underpinnings to biomechanical alterations. Beginning with an examination of genetic predispositions and cellular signaling pathways, we delve into the mechanisms driving myocardial structural changes and electrical remodeling in response to pacing stimuli. Insights into the dynamic interplay between pacing strategies and adaptive or maladaptive remodeling processes are synthesized, shedding light on the clinical implications for patients with various cardiovascular pathologies. By bridging the gap between basic science discoveries and clinical translation, this review aims to provide a comprehensive understanding of cardiac remodeling in the context of ventricular pacing, paving the way for future advancements in cardiovascular care.

Keywords: cardiac remodeling; pacing.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Major pathophysiological pathways involved in cardiac remodeling in patients with permanent right ventricular apical pacing.
See this image and copyright information in PMC

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