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. 2024 Jun 3;11(6):566.
doi: 10.3390/bioengineering11060566.

Healing of Extraction Sites after Alveolar Ridge Preservation Using Advanced Platelet-Rich Fibrin: A Retrospective Study

Antonia Samia Khaddour  1 , Răzvan Eugen Ghiță  1 , Mihaela Ionescu  2 , Radu Gabriel Rîcă  3 , Veronica Mercuț  4 , Horia Octavian Manolea  5 , Adrian Camen  6 , Emma Cristina Drăghici  1 , Andrei Radu  1 , Sanda Mihaela Popescu  1
Affiliations

Healing of Extraction Sites after Alveolar Ridge Preservation Using Advanced Platelet-Rich Fibrin: A Retrospective Study

Antonia Samia Khaddour et al. Bioengineering (Basel). .

Abstract

Background: Over time, numerous surgical procedures and biomaterials have been proposed for the reconstruction of post-extraction bone defects, each with their advantages and disadvantages. The main objective of this study was to evaluate dimensional changes in the alveolar bone 3 months after tooth extraction, before implant planning, comparing alveolar ridge preservation (ARP) with spontaneous healing.

Methods: A total of 84 patients with non-restorable molars were included in the study. Forty-two patients received ARP with advanced platelet-rich fibrin (A-PRF) and spontaneous healing was evaluated in these patients. Cone beam computed tomography (CBCT) analysis performed before and after surgical intervention was used to determine the changes in vertical and horizontal bone dimensions produced after tooth extraction.

Results: CBCT measurements showed reduction in both vertical and horizontal alveolar bone size in both groups. For the study group, the alveolar parameters (height, width) were higher compared to the control group. The percentage variations between dimensional differences from the two groups were 38.58% for height, and for width were 36.88% at 0 mm, 35.56% at 3 mm, 36.61% at 5 mm, and 38.73% at 7 mm. The differences were statistically significant (p ˂ 0.0005).

Conclusions: The results obtained after ARP with A-PRF showed a reduced loss of bone volume compared to spontaneous healing.

Keywords: advanced platelet-rich fibrin; alveolar ridge preservation; bone loss; cone beam computed tomography systems; extraction sites; horizontal changes; socket preservation; vertical changes.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Advanced platelet-rich fibrin (A-PRF) membranes obtained after pressure applied onto buffy coat of centrifuged blood.
Figure 2
Figure 2
(A) Post-extractional alveoli. (B) Alveoli cu APRF and flattened collagen sponge and suture. (C) Surgical sites 7 days after the intervention.
Figure 3
Figure 3
(a) Initial horizontal and vertical measurements; (b) Final horizontal and vertical measurements.
Figure 4
Figure 4
Distribution of subjects according to gender and residence area.
Figure 5
Figure 5
Distribution of subjects according to extraction etiology.
Figure 6
Figure 6
Distribution of subjects in relation to the extraction sites.
Figure 7
Figure 7
(a) Pre-operative CBCT at the level of the left mandibular first molar (36); (b) 3 months postoperative CBCT at the level of the left mandibular first molar (36); (c) Pre-operative CBCT at the level of the right maxillary first molar (16); (d) 3 months postoperative CBCT at the level of the right maxillary first molar (16).
Figure 8
Figure 8
Measurements before (“Pre” values) and after (“Post” values) the surgical intervention for (a) A-PRF group and (b) control group.
Figure 9
Figure 9
Measurements post-extraction: group comparison.
Figure 10
Figure 10
Maxillary and mandible differences between “Pre” and “Post” values for (a) A-PRF group and (b) control group.
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