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Review
. 2024 Jun 18;16(12):2257.
doi: 10.3390/cancers16122257.

The Anticancer Application of Delivery Systems for Honokiol and Magnolol

Katarzyna Dominiak  1 , Aleksandra Gostyńska  1 , Michał Szulc  2 , Maciej Stawny  1
Affiliations
Review

The Anticancer Application of Delivery Systems for Honokiol and Magnolol

Katarzyna Dominiak et al. Cancers (Basel). .

Abstract

Cancer is a leading cause of death worldwide, and the effectiveness of treatment is consistently not at a satisfactory level. This review thoroughly examines the present knowledge and perspectives of honokiol (HON) in cancer therapeutics. The paper synthesizes critical insights into the molecular mechanisms underlying the observed anticancer effects, emphasizing both in vitro and in vivo studies. The effects of HON application, primarily in the common types of cancers, are presented. Because the therapeutic potential of HON may be limited by its physicochemical properties, appropriate delivery systems are sought to overcome this problem. This review discusses the effect of different nanotechnology-based delivery systems on the efficiency of HON. The data presented show that HON exhibits anticancer effects and can be successfully administered to the site of action. Honokiol exerts its anticancer activity through several mechanisms. Moreover, some authors used the combinations of classical anticancer drugs with HON. Such an approach is very interesting and worth further investigation. Understanding HON's multiple molecular mechanisms would provide valuable insights into how HON might be developed as an effective therapeutic. Therefore, further research is needed to explore its specific applications and optimize its efficacy in diverse cancer types.

Keywords: bioactive natural compounds; cancer; drug delivery system; honokiol; nanoparticles.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Structure and properties of magnolia-derived bioactive compounds.
Figure 2
Figure 2
Key findings related to breast cancer.
Figure 3
Figure 3
Key findings related to glioblastoma.
Figure 4
Figure 4
Key findings related to ovarian cancer.
Figure 5
Figure 5
Key findings related to lung cancer.
Figure 6
Figure 6
Key findings related to liver cancer.
See this image and copyright information in PMC

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