Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jun 8;25(12):6348.
doi: 10.3390/ijms25126348.

Modulation of Gut Microbial Biomarkers and Metabolites in Cancer Management by Tea Compounds

Hoi Kit Matthew Leung  1 , Emily Kwun Kwan Lo  1 , Fangfei Zhang  1 , Felicianna  1 , Marsena Jasiel Ismaiah  1 , Congjia Chen  1 , Hani El-Nezami  1   2
Affiliations
Review

Modulation of Gut Microbial Biomarkers and Metabolites in Cancer Management by Tea Compounds

Hoi Kit Matthew Leung et al. Int J Mol Sci. .

Abstract

Cancers are causing millions of deaths and leaving a huge clinical and economic burden. High costs of cancer drugs are limiting their access to the growing number of cancer cases. The development of more affordable alternative therapy could reach more patients. As gut microbiota plays a significant role in the development and treatment of cancer, microbiome-targeted therapy has gained more attention in recent years. Dietary and natural compounds can modulate gut microbiota composition while providing broader and more accessible access to medicine. Tea compounds have been shown to have anti-cancer properties as well as modulate the gut microbiota and their related metabolites. However, there is no comprehensive review that focuses on the gut modulatory effects of tea compounds and their impact on reshaping the metabolic profiles, particularly in cancer models. In this review, the effects of different tea compounds on gut microbiota in cancer settings are discussed. Furthermore, the relationship between these modulated bacteria and their related metabolites, along with the mechanisms of how these changes led to cancer intervention are summarized.

Keywords: cancer; gut microbiota; metabolites; microbiome targeted therapy; tea compounds.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
Summary of the gut microbial modulatory effect of tea compounds in colorectal cancer, hepatocellular carcinoma, and lung cancer.
Figure 2
Figure 2
Summary of metabolites synthesized by tea compounds modulated gut microbiota in cancer management.
Figure 3
Figure 3
Summary of mechanisms involved in the modulation of gut microbiota by tea compounds in cancer management.
See this image and copyright information in PMC

References

    1. World Health Organization Global Cancer Burden Growing, Amidst Mounting Need for Services. [(accessed on 3 April 2024)]. Available online: https://www.who.int/news/item/01-02-2024-global-cancer-burden-growing--a.... - PMC - PubMed
    1. Han B., Zheng R., Zeng H., Wang S., Sun K., Chen R., Li L., Wei W., He J. Cancer incidence and mortality in China, 2022. J. Natl. Cancer Cent. 2024;46:221–231. doi: 10.1016/j.jncc.2024.01.006. - DOI - PubMed
    1. Lin H.-Y., Park J.Y. Anesthesia for Oncological Surgery. Springer; Berlin/Heidelberg, Germany: 2024. Epidemiology of Cancer; pp. 11–16.
    1. Siddiqui M., Rajkumar S.V. The high cost of cancer drugs and what we can do about it. Mayo Clin. Proc. 2012;87:935–943. doi: 10.1016/j.mayocp.2012.07.007. - DOI - PMC - PubMed
    1. Elinav E., Garrett W.S., Trinchieri G., Wargo J. The cancer microbiome. Nat. Rev. Cancer. 2019;19:371–376. doi: 10.1038/s41568-019-0155-3. - DOI - PMC - PubMed