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Editorial
. 2024 Jun 20;25(12):6767.
doi: 10.3390/ijms25126767.

Bone Development and Growth

Affiliations
Editorial

Bone Development and Growth

José M López. Int J Mol Sci. .

Abstract

Our skeleton is an essential part of our body consisting of 206 pieces made of a specialized form of connective tissue, with a matrix containing collagen fibers and a large amount of minerals [...].

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Conflict of interest statement

The author declares no conflicts of interest.

Figures

Figure 1
Figure 1
Formation of the epiphyseal bone plate in the tibial epiphysis of a 35-day-old rat. (A) Section stained with von Kossa showing thin bony extensions bridging the epiphyseal bone plate and the growth plate. The boxed area is shown at a higher magnification in (B) SEM image showing the epiphyseal plate (arrows) and the continuity of the bone plate with the trabecular meshwork of the epiphysis. (C) SEM image showing the epiphyseal plate (arrows) between the trabecular bone of epiphysis and diaphysis. (D) Confocal microscopy image of a 3D projection reconstructed from z-stack images showing the foramina of the plate through which blood vessels passed (arrows). (E) Paraffin section stained with Alcian blue/acid fuchsin showing that the collagen fibers are densely packed but are not arranged in a regular parallel pattern (arrows) [11].

References

    1. Burr D.B., Akkus O. Bone Morphology and Organization. In: Burr D.B., Allen M.R., editors. Basic and Applied Bone Biology. Academic Press Inc.; San Diego, CA, USA: 2014. pp. 3–25.
    1. Hall B.K. Bone. In: Hall B.K., editor. Bones and Cartilage. 2nd ed. Elsevier Science Publishing Co., Inc.; Amsterdam, The Netherlands: Academic Press Inc.; San Diego, CA, USA: 2015. pp. 17–42.
    1. Shapiro F. Pediatric Orthopedic Deformities. Volume 1. Springer International Publishing; Cham, Switzerland: 2016. Developmental Bone Biology; pp. 1–158.
    1. Xie M., Chagin A.S. The epiphyseal secondary ossification center: Evolution, development and function. Bone. 2021;142:115701. doi: 10.1016/j.bone.2020.115701. - DOI - PubMed
    1. Hunziker E.B. Mechanism of longitudinal bone growth and its regulation by growth plate chondrocytes. Microsc. Res. Techniq. 1994;28:505–519. doi: 10.1002/jemt.1070280606. - DOI - PubMed

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