Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2024 Jun 7;14(6):738.
doi: 10.3390/life14060738.

Histoplasmosis in Taiwan: Case Summary and Literature Review

Jui-Chi Hsu  1 , Po-Hsun Chang  2 , Chien-Hsiang Tai  1   3 , Yi-Chun Chen  1   4
Affiliations
Review

Histoplasmosis in Taiwan: Case Summary and Literature Review

Jui-Chi Hsu et al. Life (Basel). .

Abstract

Histoplasmosis is a global infection caused by the thermally dimorphic fungus, Histoplasma capsulatum complex. It is endemic in the United States, as well as in Central and South America. In Taiwan, histoplasmosis is rare, with the first reported case not occurring until 1977. We summarized a total of 17 cases reported in Taiwan over the past 40 years and provided detailed descriptions for four probable indigenous cases. Due to the lack of rapid diagnostic tools and clinical suspicion, histoplasmosis may be underdiagnosed in Taiwan. We recognize that a limitation of our review is the lack of data on the environmental surveillance for H. capsulatum complex in Taiwan. Conducting a further phylogenetic analysis on both environmental and clinical isolates would provide valuable evidence for the region.

Keywords: Histoplasma capsulatum; Taiwan; dimorphic fungi; endemic fungi; galactomannan.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflicts of interest.

References

    1. Araúz A.B., Papineni P. Histoplasmosis. Infect. Dis. Clin. N. Am. 2021;35:471–491. doi: 10.1016/j.idc.2021.03.011. - DOI - PubMed
    1. Kauffman C.A. Histoplasmosis: A Clinical and Laboratory Update. Clin. Microbiol. Rev. 2007;20:115–132. doi: 10.1128/CMR.00027-06. - DOI - PMC - PubMed
    1. Gugnani H.C., Muotoe-Okafor F. African histoplasmosis: A review. Rev. Iberoam. Micol. 1997;14:155–159. - PubMed
    1. Sepúlveda V.E., Márquez R., Turissini D.A., Goldman W.E., Matute D.R. Genome sequences reveal cryptic speciation in the human pathogen Histoplasma capsulatum. MBio. 2017;8:1110–1128. doi: 10.1128/mBio.01339-17. - DOI - PMC - PubMed
    1. Tenório B.G., Kollath D.R., Gade L., Litvintseva A.P., Chiller T., Jenness J.S., Stajiche J.E., Matute D.R., Hanzlicek A.S., Barker B.M., et al. Tracing histoplasmosis genomic epidemiology and species occurrence across the USA. Emerg. Microbes Infect. 2024;13:2315960. doi: 10.1080/22221751.2024.2315960. - DOI - PMC - PubMed

LinkOut - more resources