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. 2024 Jun 14;16(12):1871.
doi: 10.3390/nu16121871.

Can Diet Alter the Intestinal Barrier Permeability in Healthy People? A Systematic Review

Daniele de Souza Marinho do Nascimento  1 , Ana Carolina Costa Campos Mota  2 , Maria Clara da Cruz Carvalho  1 , Eva Débora de Oliveira Andrade  1 , Érika Paula Silva Freitas de Oliveira  2 , Liana Letícia Paulino Galvão  1 , Bruna Leal Lima Maciel  1   2   3
Affiliations

Can Diet Alter the Intestinal Barrier Permeability in Healthy People? A Systematic Review

Daniele de Souza Marinho do Nascimento et al. Nutrients. .

Abstract

Dietary factors can modify the function of the intestinal barrier, causing permeability changes. This systematic review analyzed evidence on the link between diet or dietary interventions and changes in intestinal barrier permeability (IBP) in healthy individuals. A systematic search for primary studies was conducted using the virtual databases EMBASE, PubMed, Web of Science, CINAHL, and Scopus. This review adhered to PRISMA 2020 guidelines, assessing the methodological quality using the Newcastle-Ottawa scale for observational studies and ROB 2.0 for randomized clinical trials. Out of 3725 studies recovered, 12 were eligible for review. Chicory inulin and probiotics reduced IBP in adults with a moderate GRADE level of evidence. The opposite result was obtained with fructose, which increased IBP in adults, with a very low GRADE level of evidence. Only intervention studies with different dietary components were found, and few studies evaluated the effect of specific diets on the IBP. Thus, there was no strong evidence that diet or dietary interventions increase or decrease IBP in healthy individuals. Studies on this topic are necessary, with a low risk of bias and good quality of evidence generated, as there is still little knowledge on healthy populations.

Keywords: diet; healthy people; intestinal barrier permeability.

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Conflict of interest statement

The authors declare no conflicts of interest.

Figures

Figure 1
Figure 1
PRISMA flowchart of the included studies.
See this image and copyright information in PMC

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