Population Pharmacokinetics in Oncology and Its Clinical Applications

Nicolas Widmer^{1

2

3}, Monia Guidi^{1

3

4}, Thierry Buclin¹

Affiliations

¹ Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
² Pharmacy of the Eastern Vaud Hospitals, 1847 Rennaz, Switzerland.
³ Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, 1205 Geneva, Switzerland.
⁴ Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.

Editorial

Nicolas Widmer et al. Pharmaceutics. 2024.

. 2024 May 25;16(6):711.

doi: 10.3390/pharmaceutics16060711.

Nicolas Widmer^{1

2

3}, Monia Guidi^{1

3

4}, Thierry Buclin¹

¹ Service of Clinical Pharmacology, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.
² Pharmacy of the Eastern Vaud Hospitals, 1847 Rennaz, Switzerland.
³ Institute of Pharmaceutical Sciences of Western Switzerland, University of Geneva, University of Lausanne, 1205 Geneva, Switzerland.
⁴ Center for Research and Innovation in Clinical Pharmaceutical Sciences, Lausanne University Hospital and University of Lausanne, 1011 Lausanne, Switzerland.

Abstract

Most traditional cytotoxic drugs are characterized by steep dose-response relationships and narrow therapeutic windows [...].

The authors declare no conflicts of interest.

1. de Jonge M.E., Huitema A.D., Schellens J.H., Rodenhuis S., Beijnen J.H. Individualised cancer chemotherapy: Strategies and performance of prospective studies on therapeutic drug monitoring with dose adaptation: A review. Clin. Pharmacokinet. 2005;44:147–173. doi: 10.2165/00003088-200544020-00002. - DOI - PubMed
1. Paci A., Veal G., Bardin C., Leveque D., Widmer N., Beijnen J., Astier A., Chatelut E. Review of therapeutic drug monitoring of anticancer drugs part one—Cytotoxics. Eur. J. Cancer. 2014;50:2010–2019. doi: 10.1016/j.ejca.2014.04.014. - DOI - PubMed
1. Zhang J., Yang P.L., Gray N.S. Targeting cancer with small molecule kinase inhibitors. Nat. Rev. Cancer. 2009;9:28–39. doi: 10.1038/nrc2559. - DOI - PubMed
1. Song I.W., Vo H.H., Chen Y.S., Baysal M.A., Kahle M., Johnson A., Tsimberidou A.M. Precision Oncology: Evolving Clinical Trials across Tumor Types. Cancers. 2023;15:1967. doi: 10.3390/cancers15071967. - DOI - PMC - PubMed
1. Cardoso E., Guidi M., Blanchet B., Schneider M.P., Decosterd L.A., Buclin T., Csajka C., Widmer N. Therapeutic Drug Monitoring of Targeted Anticancer Protein Kinase Inhibitors in Routine Clinical Use: A Critical Review. Ther. Drug Monit. 2020;42:33–44. doi: 10.1097/FTD.0000000000000699. - DOI - PubMed