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Review
. 2024 May 31;16(6):748.
doi: 10.3390/pharmaceutics16060748.

Comprehensive Insight into Cutaneous Application of Hemp

Ana Žugić  1 , Milica Martinović  2 , Vanja Tadić  1 , Miloš Rajković  1 , Gordana Racić  3 , Ivana Nešić  2 , Anamarija Koren  4
Affiliations
Review

Comprehensive Insight into Cutaneous Application of Hemp

Ana Žugić et al. Pharmaceutics. .

Abstract

Known for its natural bio-compounds and therapeutic properties, hemp is being utilized in the development of skin products. These products offer a wide range of applications and benefits in the fields of natural bio-compounds, pharmaceutical technology, topical delivery systems, and cosmeceuticals. This manuscript deals with hemp actives, such as cannabinoids, terpenes, and flavonoids, and their diverse biological properties relative to topical application, including anti-inflammatory, antimicrobial, and antioxidant effects. Also, the paper reviews strategies to overcome poor penetration of hemp actives, as well as the integration of hemp actives in cosmeceuticals that provide natural and sustainable alternatives to traditional skincare products offering a range of benefits, including anti-aging, moisturizing, and soothing properties. The review aims to provide a comprehensive understanding of the development and manufacturing processes of skin products containing hemp actives. By delving into the science behind hemp-based products, the paper provides valuable insights into the potential of hemp as a versatile ingredient in the pharmaceutical and cosmetic industries. The utilization of hemp in these innovative products not only offers therapeutic benefits but also promotes natural and sustainable approaches to skincare.

Keywords: circular bioeconomy; cosmeceuticals; hemp; natural bio-compounds; topical delivery systems.

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Conflict of interest statement

The authors declare no conflicts of interest. The funders had no role in the writing of the manuscript or in the decision to publish the results.

Figures

Figure 1
Figure 1
Expansion of scientific research on hemp found on Scopus in the last 20 years (2004–2024): (a) 9255 papers were found when the search was restricted to the term “hemp” as the keyword, (b) 4961 papers were found when the search was restricted to the term “hemp” and “skin” in all fields.
Figure 2
Figure 2
The main cannabinoids present in the hemp extracts.
Figure 3
Figure 3
Terpenoids present in essential oils are obtained from the hemp aerial part.
Figure 4
Figure 4
C- and O-forming flavonoid aglycones and C-glycosides are present in hemp extracts.
Figure 5
Figure 5
Unsaturated fatty acids from hemp seed oil.
Figure 6
Figure 6
Emulsion-type vehicles for topical drug delivery.
See this image and copyright information in PMC

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References

    1. Ryz N.R., Remillard D.J., Russo E.B. Cannabis Roots: A Traditional Therapy with Future Potential for Treating Inflammation and Pain. Cannabis Cannabinoid Res. 2017;2:210–216. doi: 10.1089/can.2017.0028. - DOI - PMC - PubMed
    1. Radwan M.M., Chandra S., Gul S., ElSohly M.A. Cannabinoids, Phenolics, Terpenes and Alkaloids of Cannabis. Molecules. 2021;26:2774. doi: 10.3390/molecules26092774. - DOI - PMC - PubMed
    1. Mnekin L., Ripoll L. Topical Use of Cannabis sativa L. Biochemicals. Cosmetics. 2021;8:85. doi: 10.3390/cosmetics8030085. - DOI
    1. Grof C.P.L. Cannabis, from plant to pill. Br. J. Clin. Pharmacol. 2018;84:2463–2467. doi: 10.1111/bcp.13618. - DOI - PMC - PubMed
    1. Pieracci Y., Fulvio F., Isca V., Pistelli L., Bassolino L., Montanari M., Paris R. The phenological stage of hemp inflorescences affects essential oil yield and its chemical composition. Ind. Crops Prod. 2023;197:116605. doi: 10.1016/j.indcrop.2023.116605. - DOI

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