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Case Reports
. 2024 Mar 12;48(4):294-298.
doi: 10.1080/01658107.2024.2303708. eCollection 2024.

Millard-Gubler Syndrome in a Patient with Preeclampsia. Case Report and Review of Combined Intra- and Extra-Axial Facial and Abducens Nerve Injuries

Paula Andrea Sánchez Moscoso  1   2   3 , Ana Milena Bautista Torres  1   2   3 , Francisco Javier Bonilla-Escobar  1   2   3   4   5 , Omar Fernando Salamanca Libreros  1   2   3
Affiliations
Case Reports

Millard-Gubler Syndrome in a Patient with Preeclampsia. Case Report and Review of Combined Intra- and Extra-Axial Facial and Abducens Nerve Injuries

Paula Andrea Sánchez Moscoso et al. Neuroophthalmology. .

Abstract

Millard-Gubler syndrome is a pontine syndrome caused by a lesion in the lower pons region. It is characterised by ipsilateral facial paralysis and VI paresis and contralateral brachiocrural palsy. We present the case of a female patient, G4P2A1, at 21 weeks of gestation, with preeclampsia, complaints of blurred vision, diplopia, and right hemiparesis, in whom a clinical diagnosis of Millard-Gubler syndrome was made. Neuroimaging showed an intraparenchymal haemorrhage towards the central portion of the bulbopontine junction. An extensive aetiological study was carried out to determine the cause of the hypertensive disorder syndrome during pregnancy. The patient improved satisfactorily from the neurological deficit after delivery of an early stillbirth.

Keywords: Millard-gubler syndrome; cerebrovascular disease; hypertension; pontine haemorrhage; preeclampsia; pregnant; sixth and seventh cranial nerve palsies.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
(a) Primary gaze position, mild supranuclear left facial palsy. (b) Dextroversion. (c) Levoversion.
Figure 2.
Figure 2.
Non-contrast and contrasted brain MRI T1-weight images in sagittal, coronal and axial sections.
See this image and copyright information in PMC

References

    1. James AH, Bushnell CD, Jamison MG, Myers ER.. Incidence and risk factors for stroke in pregnancy and the puerperium. Obstet Gynecol. 2005;106(3):509–16. doi:10.1097/01.AOG.0000172428.78411.b0. - DOI - PubMed
    1. Hypertension G. The American college of obstetricians and gynecologists, 2020.Gestational hypertension and preeclampsia: ACOG practice bulletin summary, number 222. Obstet Gynecol. 2020;135:1492–1495. - PubMed
    1. Kaplovitch E, Anand SS. Stroke in women recognizing opportunities for prevention and treatment. Stroke. 2018;49(3):515–517. doi:10.1161/STROKEAHA.117.020354. - DOI - PubMed
    1. Sakuru R, Elnahry AG, Bollu PC. Millard-Gubler Syndrome. Treasure Island, FL: StatPearls Publishing; 2022. http://europepmc.org/books/NBK532907. - PubMed
    1. Brazis PW, Masdeu J, Biller J. Localization in Clinical Neurology. 6th ed. Philadelphia, PA: Lippincott Williams & Wilkins; 2011.

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