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Multicenter Study
. 2024 Jun 12:15:1374682.
doi: 10.3389/fendo.2024.1374682. eCollection 2024.

Impact of breastfeeding on risk of glucose intolerance in early postpartum after gestational diabetes

Yana Vanlaer  1 , Caro Minschart  1 , Hannah Vrolijk  2 , Paul Van Crombrugge  3 , Carolien Moyson  1 , Johan Verhaeghe  4 , Roland Devlieger  4   5   6 , Sofie Vandeginste  7 , Hilde Verlaenen  7 , Chris Vercammen  8 , Toon Maes  8 , Els Dufraimont  9 , Nele Roggen  9 , Christophe De Block  10 , Yves Jacquemyn  11   12 , Farah Mekahli  13 , Katrien De Clippel  14 , Annick Van Den Bruel  15 , Anne Loccufier  16 , Inge Van Pottelbergh  17 , Nele Myngheer  18 , Pascale Abrams  19   20 , Wouter Vinck  20 , Liesbeth Leuridan  21 , Sabien Driessens  21 , Jaak Billen  22 , Christophe Matthys  23 , Annick Bogaerts  24   25 , Annouschka Laenen  26 , Chantal Mathieu  1 , Katrien Benhalima  1
Affiliations
Multicenter Study

Impact of breastfeeding on risk of glucose intolerance in early postpartum after gestational diabetes

Yana Vanlaer et al. Front Endocrinol (Lausanne). .

Abstract

Aims: To determine the impact of breastfeeding on the risk of postpartum glucose intolerance in women with gestational diabetes.

Methods: Sub-analysis of two multi-centric prospective cohort studies (BEDIP-N and MELINDA) in 1008 women with gestational diabetes. Data were collected during pregnancy and at a mean of 12 weeks postpartum. Multivariate logistic regression was used to estimate the effect of breastfeeding on glucose intolerance, with adjustment for ethnicity, education, income, professional activity and BMI.

Results: Of all participants, 56.3% (567) breastfed exclusively, 10.1% (102) gave mixed milk feeding and 33.6% (339) did not breastfeed. Mean breastfeeding duration was 3.8 ± 2.4 and 3.7 ± 2.1 months in the breastfeeding and mixed milk feeding groups (p=0.496). The rate of glucose intolerance was lower in both the breastfeeding [22.3% (126)] and mixed milk feeding [25.5% (26)] groups compared to the no breastfeeding group [29.5% (100)], with an adjusted OR of 0.7 (95% CI 0.5-1.0) for glucose intolerance in the breastfeeding group compared to no breastfeeding group and an adjusted OR of 0.7 (95% CI 0.4-1.2) for the mixed milk feeding group compared to the no breastfeeding group. Postpartum, breastfeeding women had a lower BMI, less often postpartum weight retention, lower fasting triglycerides, less insulin resistance and a higher insulin secretion-sensitivity index-2 than the mixed milk feeding and no breastfeeding group. The mixed milk feeding group was more often from an non-White background, had a lower blood pressure and lower fasting triglycerides compared to the no breastfeeding group.

Conclusions: Breastfeeding (exclusive and mixed milk feeding) is associated with less glucose intolerance and a better metabolic profile in early postpartum in women with gestational diabetes.

Keywords: breastfeeding; gestational diabetes mellitus; impaired beta-cell function; insulin resistance; mixed milk feeding; postpartum glucose intolerance.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Flow chart of the total cohort included in the sub-analysis.
See this image and copyright information in PMC

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