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. 2024 Dec;13(1):2373308.
doi: 10.1080/22221751.2024.2373308. Epub 2024 Jul 22.

Genomic characterization of a reemerging Chikungunya outbreak in Kedougou, Southeastern Senegal, 2023

Idrissa Dieng  1 , Bacary Djilocalisse Sadio  1 , Alioune Gaye  2 , Samba Niang Sagne  3 , Marie Henriette Dior Ndione  1 , Mouhamed Kane  1 , Mamadou Korka Diallo  3 , Bocar Sow  3 , Safietou Sankhe  1 , Ousseynou Sene  1 , Amadou Diallo  3 , Madeleine Dieng  1 , Serge Freddy Moukaha Doukanda  1 , Maimouna Mbanne  1 , Seynabou Mbaye Ba Souna Diop  1 , Diamilatou Balde  1 , Mignane Ndiaye  1 , Khalidou Djibril Sow  4 , Maryam Diarra  3 , Abdoulaye Sam  5 , Ababacar Mbaye  6 , Boubacar Diallo  7 , Yoro Sall  5 , Ousmane Faye  7 , Boly Diop  5 , Abdourahmane Sow  7   8 , Amadou Alpha Sall  1 , Cheikh Loucoubar  3 , Ndongo Dia  1 , Oumar Faye  1 , Diawo Diallo  2 , Gamou Fall  1 , Scott C Weaver  9 , Mamadou Aliou Barry  3 , Mawlouth Diallo  2 , Moussa Moise Diagne  1
Affiliations

Genomic characterization of a reemerging Chikungunya outbreak in Kedougou, Southeastern Senegal, 2023

Idrissa Dieng et al. Emerg Microbes Infect. 2024 Dec.

Abstract

Chikungunya virus has caused millions of cases worldwide over the past 20 years, with recent outbreaks in Kedougou region in the southeastern Senegal, West Africa. Genomic characterization highlights that an ongoing epidemic in Kedougou in 2023 is not due to an introduction event but caused by the re-emergence of an endemic strain evolving linearly in a sylvatic context.

Keywords: Chikungunya; Kedougou; Southeastern Senegal; genomic characterization; outbreak.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Time-scaled phylogenetic tree of sequenced CHIKV strains sampled during Kédougou outbreak in 2023. The tree was constructed using nearly complete genomes of CHIKV. Parent node of the outbreak sequences is annotated with tMRCA and 95% HPD interval of node age.
Figure 2.
Figure 2.
Phylogenetic relationship of newly generated CHIKV sequences and those previously available. Tree was annotated with country, year of sampling and host of West African genotype viral sequences. Only bootstrap values above 70 were represented on corresponding branches. Root-to-tip regression and time-scaled phylogenetic analysis show linear evolution between newly generated Chikungunya virus sequences obtained from the ongoing outbreak in Senegal 2023 and those from 2015 in Kedougou and the other West African genotype sequences.
See this image and copyright information in PMC

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