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. 1985 Jun 28;129(3):701-6.
doi: 10.1016/0006-291x(85)91948-5.

A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin

F Gejyo, T Yamada, S Odani, Y Nakagawa, M Arakawa, T Kunitomo, H Kataoka, M Suzuki, Y Hirasawa, T Shirahama, et al.

A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin

F Gejyo et al. Biochem Biophys Res Commun. .

Abstract

Amyloid fibrils were isolated from amyloid-laden tissue obtained from a chronic hemodialysis patient with carpal tunnel syndrome. After solubilization in guanidine HCl, a significant amount of the protein was located in a homogeneous low molecular weight fraction. The protein was found to be identical to beta 2-microglobulin, with regard to its molecular weight of 11,000, amino acid composition and 16 amino-terminal amino acids: Ile-Gln-Arg-Thr-Pro-Lys-Ile-Gln-Val-Tyr-Ser-Arg-His-Pro-Ala-Glu-. These results demonstrate that the amyloid associated with chronic hemodialysis contains as major component a new form of amyloid fibril protein that is homologous to beta 2-microglobulin.

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