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. 2024 Sep;205(3):1137-1146.
doi: 10.1111/bjh.19603. Epub 2024 Jun 27.

Relevance of repeated analyses of albuminuria and glomerular filtration rate in African children with sickle cell anaemia

Agathe B Nkoy  1   2 , Floreen M Mumaka  1 , Ange Ngonde  3 , Samuel K Mafumba  4 , Therance T Matoka  1 , Robert Kitenge  5 , Flore M Talu  1 , Blaise Nkolomoni  6 , Léon Tshilolo  5 , Lambertus P van den Heuvel  2   7 , Pépé M Ekulu  1 , Elena N Levtchenko  2   8 , Veerle Labarque  9   10
Affiliations

Relevance of repeated analyses of albuminuria and glomerular filtration rate in African children with sickle cell anaemia

Agathe B Nkoy et al. Br J Haematol. 2024 Sep.

Abstract

Glomerular hyperfiltration and albuminuria are frequent kidney abnormalities in children with sickle cell anaemia (SCA). However, little is known about their persistence in African SCA children. This prospective study included 600 steady-state SCA children aged 2-18 years from the Democratic Republic of Congo. Participants were genotyped for apolipoprotein L1 (APOL1) risk variants (RVs) and haem oxygenase-1 (HMOX1) GT-dinucleotide repeats. Kidney abnormalities were defined as albuminuria, hyperfiltration or decreased estimated creatinine-based glomerular filtration rate (eGFRcr). At baseline, 247/600 (41.2%) participants presented with kidney abnormalities: 82/592 (13.8%) with albuminuria, 184/587 (31.3%) with hyperfiltration and 15/587 (2.6%) with decreased eGFRcr. After a median follow-up of 5 months, repeated testing was performed in 180/247 (72.9%) available participants. Persistent hyperfiltration and persistent albuminuria (PA) were present in 29.2% (38/130) and 39.7% (23/58) respectively. eGFR normalized in all participants with a baseline decreased eGFRcr. Haemoglobinuria (p = 0.017) and male gender (p = 0.047) were significantly associated with PA and persistent hyperfiltration respectively. APOL1 RVs (G1G1/G2G2/G1G2) were borderline associated with PA (p = 0.075), while HMOX1 long repeat was not associated with any persistent kidney abnormality. This study reveals that a single screening can overestimate the rate of kidney abnormalities in children with SCA and could lead to overtreatment.

Keywords: APOL1; HMOX1; children; persistent kidney disease; sickle cell disease.

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References

REFERENCES

    1. Kato GJ, Piel FB, Reid CD, Gaston MH, Ohene‐Frempong K, Krishnamurti L, et al. Sickle cell disease. Nat Rev Dis Prim. 2018;4(1):18010.
    1. Adebayo O, Nkoy A, Cheng C, Levtchenko E, Van den Heuvel L, Labarque V. Sickle cell disease: a neglected haemoglobinopathy disorder with a huge global burden. Belg J Hematol. 2023;14(12):41–58.
    1. Adebayo OC, Van den Heuvel LP, Olowu WA, Levtchenko EN, Labarque V. Sickle cell nephropathy: insights into the pediatric population. Pediatr Nephrol. 2022;37(6):1231–1243.
    1. Ataga KI, Saraf SL, Derebail VK. The nephropathy of sickle cell trait and sickle cell disease. Nat Rev Nephrol. 2022;18:361–377.
    1. Adebayo OC, Nkoy AB, van den Heuvel LP, Labarque V, Levtchenko E, Delanaye P, et al. Glomerular hyperfiltration: part 2—clinical significance in children. Pediatr Nephrol. 2022;1:1–19.