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. 2024 Jul 11;20(3):293-298.
doi: 10.1007/s13181-024-01020-1. Epub 2024 Jun 27.

From Patient Registry to Multi-Center Research Consortium: the Toxicology Investigators Consortium (ToxIC) Turns Fifteen

Jeffrey Brent  1   2 , Paul Wax  3 , Rachel Culbreth  3 , Sharan Campleman  3 , Kim Aldy  3   4
Affiliations

From Patient Registry to Multi-Center Research Consortium: the Toxicology Investigators Consortium (ToxIC) Turns Fifteen

Jeffrey Brent et al. J Med Toxicol. .

Abstract

The Toxicology Investigators Consortium (ToxIC) was launched as a prospective multi-center registry of cases who receive medical toxicology consultations. Now, with over 100,000 cases, the Core Registry continues to address many medical toxicology research questions and has served as the foundation for multiple sub-registries, including the North American Snakebite Registry and the Medications for Opioid Use Disorder sub-registry. ToxIC also has evolved a portfolio of non-registry-based projects utilizing medical toxicology physician site principal investigators who enroll patients through emergency departments, irrespective of whether they received a medical toxicology consultation. These studies include the FDA-ACMT COVID-19 ToxIC Pharmacovigilance Project, which identifies adverse drug reactions related to the treatment of COVID-19, the Fentalog Study a toxico-surveillance study of suspected opioid overdose cases, the Drug Overdose Toxico-Surveillance Reporting Program which enrolls either suspected stimulant or opioid overdose cases, and the just being launched Real-World Examination of Naloxone for Drug Overdose Reversal project. Given ToxIC's experience in multi-center studies and its well-developed infrastructure, it is well-positioned to provide a nimble response on the part of the medical toxicology community to addressing evolving toxicological threats, drug and chemical toxicosurveillance, and other important medical toxicology priorities.

Keywords: Epidemiology; Medical Toxicology; Overdose; Poisoning; Surveillance.

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Conflict of interest statement

None.

Figures

Fig. 1
Fig. 1
The Toxicology Investigators Consortium (ToxIC) core registry infrastructure: main registry and sub-registries/focused data collections
Fig. 2
Fig. 2
The Toxicology Investigators Consortium (ToxIC) multi-center project infrastructure
Fig. 3
Fig. 3
The Toxicology Investigators Consortium (ToxIC) program timeline
See this image and copyright information in PMC

References

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    1. Wax PM, Kleinschmidt KC, Brent J. The Toxicology investigators Consortium (ToxIC) Registry. J Med Toxicol. 2011;7(4):259–65. 10.1007/s13181-011-0177-z - DOI - PMC - PubMed
    1. Brent J, Wax PM, Schwartz T, Kleinschmidt KC, Engebretsen K, Beuhler M. The Toxicology investigators Consortium Case Registry—the 2010 experience. J Med Toxicol. 2011;7(4):266–76. 10.1007/s13181-011-0185-z - DOI - PMC - PubMed
    1. Wiegand TJ, Wax PM, Schwartz T, Finkelstein Y, Gorodetsky R, Brent J. The Toxicology investigators Consortium Case Registry—the 2011 experience. J Med Toxicol. 2012;8(4):360–77. 10.1007/s13181-012-0264-9 - DOI - PMC - PubMed
    1. Wiegand TJ, Wax PM, Smith E, Hart K, Brent J. The Toxicology investigators Consortium Case Registry—the 2012 experience. J Med Toxicol. 2013;9(4):380–404. 10.1007/s13181-013-0352-5 - DOI - PMC - PubMed

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