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Editorial
. 2024 Jun 27;143(26):2684-2686.
doi: 10.1182/blood.2024024907.

Elevating TPO production up a Notch

Hervé Falet  1 , Karin M Hoffmeister  1
Affiliations
Editorial

Elevating TPO production up a Notch

Hervé Falet et al. Blood. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflict-of-interest disclosure: The authors declare no competing financial interests.

Figures

None
Hepatic Notch 1 and platelet DLL4 are key regulators of TPO production downstream of the AMR. Notch 1 associates with the AMR subunit ASGR1 on hepatocytes. As circulating platelets age and lose sialic acid, desialylated GPIbα and DLL4 are recognized by the hepatic AMR and Notch 1, respectively. This recognition triggers an increase in HES5 mRNA expression. HES5 then associates with JAK2 and STAT3, promoting their phosphorylation and activation, ultimately resulting in an upregulation of hepatic TPO mRNA expression. NICD, Notch 1 intracellular domain.
See this image and copyright information in PMC

Comment on

  • Notch1 regulates hepatic thrombopoietin production.
    Sun Y, Tong H, Chu X, Li Y, Zhang J, Ding Y, Zhang S, Gui X, Chen C, Xu M, Li Z, Gardiner EE, Andrews RK, Zeng L, Xu K, Qiao J. Sun Y, et al. Blood. 2024 Jun 27;143(26):2778-2790. doi: 10.1182/blood.2023023559. Blood. 2024. PMID: 38603632

References

    1. Sun Y, Tong H, Chu X, et al. Notch1 regulates hepatic thrombopoietin production. Blood. 2024;143(26):2778–2790. - PubMed
    1. Falet H, Rivadeneyra L, Hoffmeister KM. Clinical impact of glycans in platelet and megakaryocyte biology. Blood. 2022;139(22):3255–3263. - PMC - PubMed
    1. Grozovsky R, Begonja AJ, Liu K, et al. The Ashwell-Morell receptor regulates hepatic thrombopoietin production via JAK2-STAT3 signaling. Nat Med. 2015;21(1):47–54. - PMC - PubMed
    1. Bray SJ. Notch signalling in context. Nat Rev Mol Cell Biol. 2016;17(11):722–735. - PubMed
    1. Grewal PK. The Ashwell-Morell receptor. Methods Enzymol. 2010;479:223–241. - PubMed