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. 2024 Jun 28;384(6703):1404-1406.
doi: 10.1126/science.adi3450. Epub 2024 Jun 27.

Neuronal senescence may drive brain aging

Joseph R Herdy  1 , Jerome Mertens  2 , Fred H Gage  1
Affiliations

Neuronal senescence may drive brain aging

Joseph R Herdy et al. Science. .

Abstract

Senescence of postmitotic neurons presents challenges and opportunities to modify brain aging.

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Figures

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Aging-associated stress triggers senescence
Neurons undergo terminal differentiation from a neural stem cell early in life followed by permanent cell cycle arrest. As a result, neurons experience a lifetime of age-associated stress, which culminates in a subpopulation with a senescent phenotype late in life. Despite being nonproliferative, senescent neurons present other common phenotypes associated with senescence.
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