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Comment

. 2024 Jun 28;384(6703):1407-1408.

doi: 10.1126/science.adq3334. Epub 2024 Jun 27.

An epigenetic editor to silence genes

Madelynn N Whittaker¹, Kiran Musunuru¹

Affiliations

PMID: 38935735
DOI: 10.1126/science.adq3334

Comment

An epigenetic editor to silence genes

Madelynn N Whittaker et al. Science. 2024.

. 2024 Jun 28;384(6703):1407-1408.

doi: 10.1126/science.adq3334. Epub 2024 Jun 27.

Authors

Madelynn N Whittaker¹, Kiran Musunuru¹

Affiliation

¹ Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.

PMID: 38935735
DOI: 10.1126/science.adq3334

Abstract

A new class of editor has improved delivery, durability, tunability, and safety.

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Comment on

Brainwide silencing of prion protein by AAV-mediated delivery of an engineered compact epigenetic editor.
Neumann EN, Bertozzi TM, Wu E, Serack F, Harvey JW, Brauer PP, Pirtle CP, Coffey A, Howard M, Kamath N, Lenz K, Guzman K, Raymond MH, Khalil AS, Deverman BE, Minikel EV, Vallabh SM, Weissman JS. Neumann EN, et al. Science. 2024 Jun 28;384(6703):ado7082. doi: 10.1126/science.ado7082. Epub 2024 Jun 28. Science. 2024. PMID: 38935715 Free PMC article.

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