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. 2024 Jun 27;62(6):myad128.
doi: 10.1093/mmy/myad128.

Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens

Tina Marinelli  1 , Hannah Yejin Kim  2   3   4 , Catriona L Halliday  5 , Katherine Garnham  6 , Olivia Bupha-Intr  7 , Aiken Dao  2   8   9 , Arthur J Morris  10 , Ana Alastruey-Izquierdo  11 , Arnaldo Colombo  12 , Volker Rickerts  13 , John Perfect  14 , David W Denning  15 , Marcio Nucci  16 , Raph L Hamers  17   18 , Alessandro Cassini  19   20 , Rita Oladele  21 , Tania C Sorrell  2   4 , Pilar Ramon-Pardo  22 , Terence Fusire  23 , Tom M Chiller  24 , Retno Wahyuningsih  25   26 , Agustina Forastiero  22 , Adi Al-Nuseirat  27 , Peter Beyer  28 , Valeria Gigante  29 , Justin Beardsley  2   30 , Hatim Sati  29 , Jan-Willem Alffenaar  2   3   4 , C Orla Morrissey  31
Affiliations

Fusarium species,Scedosporium species, and Lomentospora prolificans: A systematic review to inform the World Health Organization priority list of fungal pathogens

Tina Marinelli et al. Med Mycol. .

Abstract

Recognizing the growing global burden of fungal infections, the World Health Organization established a process to develop a priority list of fungal pathogens (FPPL). In this systematic review, we aimed to evaluate the epidemiology and impact of infections caused by Fusarium spp., Scedosporium spp., and Lomentospora prolificans to inform the first FPPL. PubMed and Web of Sciences databases were searched to identify studies published between January 1, 2011 and February 23, 2021, reporting on mortality, complications and sequelae, antifungal susceptibility, preventability, annual incidence, and trends. Overall, 20, 11, and 9 articles were included for Fusarium spp., Scedosporium spp., and L. prolificans, respectively. Mortality rates were high in those with invasive fusariosis, scedosporiosis, and lomentosporiosis (42.9%-66.7%, 42.4%-46.9%, and 50.0%-71.4%, respectively). Antifungal susceptibility data, based on small isolate numbers, showed high minimum inhibitory concentrations (MIC)/minimum effective concentrations for most currently available antifungal agents. The median/mode MIC for itraconazole and isavuconazole were ≥16 mg/l for all three pathogens. Based on limited data, these fungi are emerging. Invasive fusariosis increased from 0.08 cases/100 000 admissions to 0.22 cases/100 000 admissions over the time periods of 2000-2009 and 2010-2015, respectively, and in lung transplant recipients, Scedosporium spp. and L. prolificans were only detected from 2014 onwards. Global surveillance to better delineate antifungal susceptibility, risk factors, sequelae, and outcomes is required.

Keywords: Fusarium; Lomentospora prolificans; Scedosporium apiospermum; antifungal resistance; epidemiology; fungemia; invasive fungal disease; mortality.

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Conflict of interest statement

This manuscript has been prepared in a personal capacity by the authors and reflects their views. The views expressed must not be attributed to the WHO, its Secretariat or its member states.

Dr. David Denning and his family hold Founder shares in F2G Ltd., a University of Manchester spin-out antifungal discovery company. All the other authors have no conflicts of interest to declare.

Figures

Figure 1a.
Figure 1a.
Flow diagram for selection of studies included in the systematic review of Fusarium species. Based on: Preferred Reporting Items for Systematic Review and Meta-Analyses: The PRISMA Statement.
Figure 1b.
Figure 1b.
Flow diagram for selection of studies included in the systematic review of Scedosporium species. Based on: Preferred Reporting Items for Systematic Review and Meta-Analyses: The PRISMA Statement.
Figure 1c.
Figure 1c.
Flow diagram for selection of studies included in the systematic review of Lomentospora prolificans. Based on: Preferred Reporting Items for Systematic Review and Meta-Analyses: The PRISMA Statement.
See this image and copyright information in PMC

References

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