Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

Affiliations

¹ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain; Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès, Barcelona, Spain.
² Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER-FES). Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid 28029, Spain.
³ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain.
⁴ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER-FES). Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid 28029, Spain.
⁵ Department of Epidemiology, Harvard T.H. Chan School of Public Health. School of Public Health 2, 677 Huntington Ave, Boston, MA 02115, USA; Channing Division of Network Medicine, Harvard Medical School, Boston, MA 02115, USA.
⁶ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain; Institute of Evolutionary Biology (CSIC-UPF), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Pg. Marítim de la Barceloneta, 37, Barcelona 08003, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
⁷ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain.
⁸ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina. Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid 28029, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.
⁹ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain.
¹⁰ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Universitat Pompeu Fabra, C/ de Ramon Trias Fargas, 25, 27, Barcelona 08005, Spain. Electronic address: nvilor@barcelonabeta.org.
¹¹ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER-FES). Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid 28029, Spain; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Center (IDIBELL), Hospital Duran i Reynals, Avinguda de la Granvia de l'Hospitalet, 199-203, L'Hospitalet de Llobregat, Barcelona 08908, Spain. Electronic address: marta.crous@iconcologia.net.

PMID: 38936230
DOI: 10.1016/j.neurobiolaging.2024.05.015

Free article

Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

Blanca Rodríguez-Fernández et al. Neurobiol Aging. 2024 Sep.

Free article

. 2024 Sep:141:140-150.

doi: 10.1016/j.neurobiolaging.2024.05.015. Epub 2024 Jun 1.

Affiliations

¹ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain; Universitat Autònoma de Barcelona, 08193, Cerdanyola del Vallès, Barcelona, Spain.
² Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER-FES). Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid 28029, Spain.
³ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain.
⁴ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER-FES). Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid 28029, Spain.
⁵ Department of Epidemiology, Harvard T.H. Chan School of Public Health. School of Public Health 2, 677 Huntington Ave, Boston, MA 02115, USA; Channing Division of Network Medicine, Harvard Medical School, Boston, MA 02115, USA.
⁶ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain; Institute of Evolutionary Biology (CSIC-UPF), Department of Experimental and Health Sciences, Universitat Pompeu Fabra, Pg. Marítim de la Barceloneta, 37, Barcelona 08003, Spain; Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain.
⁷ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain.
⁸ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centro de Investigación Biomédica en Red Bioingeniería, Biomateriales y Nanomedicina. Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid 28029, Spain; Centro Nacional de Investigaciones Cardiovasculares (CNIC), C. de Melchor Fernández Almagro, 3, Madrid 28029, Spain.
⁹ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain.
¹⁰ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; IMIM - Hospital del Mar Medical Research Institute, C/ del Dr. Aiguader, 88, 2nd floor, Campus Mar, Barcelona 08003, Spain; Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, C/ del Dr. Aiguader, 88, Barcelona 08003, Spain; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Universitat Pompeu Fabra, C/ de Ramon Trias Fargas, 25, 27, Barcelona 08005, Spain. Electronic address: nvilor@barcelonabeta.org.
¹¹ Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, C/ de Wellington, 30, Barcelona 08005, Spain; Centro de Investigación Biomédica en Red de Fragilidad y Envejecimiento Saludable (CIBER-FES). Instituto de Salud Carlos III, C/ Monforte de Lemos 3-5. Pabellón 11, Planta 0, Madrid 28029, Spain; Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands; Catalan Institute of Oncology (ICO)-Bellvitge Biomedical Research Center (IDIBELL), Hospital Duran i Reynals, Avinguda de la Granvia de l'Hospitalet, 199-203, L'Hospitalet de Llobregat, Barcelona 08908, Spain. Electronic address: marta.crous@iconcologia.net.

PMID: 38936230
DOI: 10.1016/j.neurobiolaging.2024.05.015

Abstract

Introduction: Leukocyte telomere length (LTL) is an objective biomarker of biological aging, and it is proposed to play a crucial role in Alzheimer's disease (AD) risk. We aimed at evaluating the cross-sectional association between LTL and cognitive performance in middle-aged cognitively unimpaired individuals at increased risk of AD.

Methods: A total of 1520 participants from the ALFA cohort were included. Relative telomere length was measured in leukocytes through qPCR. LTL was residualized against age and sex, and associations with cognitive performance were assessed in short and long groups based on residualized LTL (rLTL). Interactions with sex and genetic risk of AD were tested.

Results: Non-linear associations were found between LTL and episodic memory (EM). Better EM was associated with longer rLTL among women in the short rLTL group.

Discussion: Results suggest a potential role of telomeres in the cognitive aging process with sex-specific patterns.

Keywords: Alzheimer’s disease; Biological aging; Cognitive performance; Sex differences; Telomere length.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests JLM is currently a full-time employee of Lundbeck and has previously served as a consultant or at advisory boards for the following for-profit companies or has given lectures in symposia sponsored by the following for-profit companies: Roche Diagnostics, Genentech, Novartis, Lundbeck, Oryzon, Biogen, Lilly, Janssen, Green Valley, MSD, Eisai, Alector, BioCross, GE Healthcare, ProMIS Neurosciences. JDG has received speaker’s or consultant's fees from Philips Nederlands, Roche Diagnostics and Biogen and research support from GE Healthcare, Roche Diagnostics and Hoffmann-La Roche. MSC has served as a consultant and at advisory boards for Roche Diagnostics International Ltd, has given lectures in symposia sponsored by Roche Diagnostics, S.L.U, Roche Farma, S.A and Roche Sistemas de Diagnósticos, Sociedade Unipessoal, Lda. and research support from Roche Diagnostics International Ltd. GSB has served as a consultant for Roche Farma, S.A. ASV has received research funding through his institution and support to attend professional meetings from the California Walnut Commission. The remaining authors declare that they have no conflict of interest.

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Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

Affiliations

Association between telomere length and cognitive function among cognitively unimpaired individuals at risk of Alzheimer's disease

Authors

Affiliations

Abstract

Conflict of interest statement

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Medical