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Review
. 2024 Jun;103(6):e15549.
doi: 10.1111/tan.15549.

25 years of the IPD-IMGT/HLA Database

James Robinson  1   2 , Dominic J Barker  1   2 , Steven G E Marsh  1   2
Affiliations
Review

25 years of the IPD-IMGT/HLA Database

James Robinson et al. HLA. 2024 Jun.

Abstract

Twenty-five years ago, in 1998, the HLA Informatics Group of the Anthony Nolan Research Institute released the IMGT/HLA Database. Since this time, this online resource has acted as the repository for the numerous variant sequences of HLA alleles named by the WHO Nomenclature Committee for Factors of the HLA System. The IPD-IMGT/HLA Database has provided a stable, highly accessible, user-friendly repository for this work. During this time, the technology underlying HLA typing has undergone significant changes. Next generation sequencing (NGS) has superseded previous methodologies of HLA typing and can generate large amounts of high-resolution sequencing data. This has resulted in a drastic increase in the number and complexity of sequences submitted to the database. The challenge for the IPD-IMGT/HLA Database has been to maintain the highest standards of curation, while supporting the core set of tools and functionality to our users with increased numbers of submissions and sequences. Traditional methods of accessing and presenting data have been challenged and new methods utilising new computing technologies have had to be developed to keep pace and support a shifting user demographic.

Keywords: alleles; database; nomenclature; polymorphism; variation.

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References

REFERENCES

    1. Robinson J, Malik A, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database—a sequence database for the human major histocompatibility complex. Tissue Antigens. 2000;55:280‐287.
    1. Ruiz M, Giudicelli V, Ginestoux C, et al. IMGT, the international ImMunoGeneTics database. Nucleic Acids Res. 2000;28:219‐221.
    1. Robinson J, Waller MJ, Parham P, Bodmer JG, Marsh SGE. IMGT/HLA database—a sequence database for the human major histocompatibility complex. Nucleic Acids Res. 2001;29:210‐213.
    1. Robinson J, Waller MJ, Parham P, et al. IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex. Nucleic Acids Res. 2003;31:311‐314.
    1. Robinson J, Marsh SGE. The IMGT/HLA Database. Methods Mol Biol. 2007;409:43‐60.

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