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Multicenter Study
. 2024 Dec 16;96(1):95-99.
doi: 10.1136/jnnp-2024-333396.

Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy

Alessandro Pezzini  1   2 , Barbara Tarantino  3 , Maria Luisa Zedde  4 , Simona Marcheselli  5 , Giorgio Silvestrelli  6 , Alfonso Ciccone  6 , Maria Luisa Delodovici  7 , Lucia Princiotta Cariddi  7 , Simone Vidale  7 , Maurizio Paciaroni  8 , Cristiano Azzini  9 , Marina Padroni  9 , Massimo Gamba  10 , Mauro Magoni  10 , Massimo Del Sette  11 , Rossana Tassi  12 , Ivo Giuseppe de Franco  12 , Anna Cavallini  13 , Rocco Salvatore Calabrò  14 , Manuel Cappellari  15 , Elisa Giorli  16 , Giacomo Giacalone  17 , Corrado Lodigiani  18 , Mara Zenorini  19 , Francesco Valletta  19 , Rosario Pascarella  20 , Giorgia Abrignani  2 , Paola Castellini  2 , Antonio Genovese  2 , Lilia Latte  2 , Maria Claudia Trapasso  2 , Ilaria Grisendi  4 , Federica Assenza  4 , Manuela Napoli  20 , Claudio Moratti  20 , Sofia Beccattini  8 , Maurizio Acampa  12 , Franco Valzania  4 , Mario Grassi  3 , Davide Gentilini  3 ; Multicenter Study on Cerebral Haemorrhage in Italy (MUCH-Italy) Investigators
Affiliations
Multicenter Study

Statin use and long-term risk of recurrent intracerebral haemorrhage: the MUCH-Italy

Alessandro Pezzini et al. J Neurol Neurosurg Psychiatry. .

Abstract

Background: Whether statin use after spontaneous intracerebral haemorrhage (ICH) increases the risk of recurrent ICH is uncertain.

Methods: In the setting of the Multicentric Study on Cerebral Haemorrhage in Italy we followed up a cohort of 30-day ICH survivors, consecutively admitted from January 2002 to July 2014, to assess whether the use of statins after the acute event is associated with recurrent cerebral bleeding.

Results: 1623 patients (mean age, 73.9±10.3 years; males, 55.9%) qualified for the analysis. After a median follow-up of 40.5 months (25th to 75th percentile, 67.7) statin use was not associated with increased risk of recurrent ICH either in the whole study group (adjusted HR, 0.99; 95% CI 0.64 to 1.53) or in the subgroups defined by haematoma location (deep ICH, adjusted HR, 0.74; 95% CI 0.35 to 1.57; lobar ICH, adjusted HR, 1.09; 95% CI 0.62 to 1.90), intensity of statins (low-moderate intensity statins, adjusted HR, 0.93; 95% CI 0.58 to 1.49; high-intensity statins, adjusted HR, 1.48; 95% CI 0.66 to 3.31) and use of statins before the index event (adjusted HR, 0.66; 95% CI 0.38 to 1.17).

Conclusions: Statin use appears to be unrelated to the risk of ICH recurrence.

Keywords: CEREBROVASCULAR DISEASE; STROKE.

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Conflict of interest statement

Competing interests: AC reports grants from Daiichi-Sankyo; grants from Italfarmaco; and grants from Alexion Pharmaceuticals. MP reports compensation from SANOFI-AVENTIS US LLC for other services; compensation from PFIZER CANADA for other services; compensation from iRhythm Technologies for other services; compensation from Daiichi Sankyo Europe GmbH for other services; and compensation from Bristol-Myers Squibb for other services. The other authors have nothing to disclose.

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