The Road Toward Clinical Implementation of Polygenic Risk Scores for Coronary Artery Disease

Marios Arvanitis^{1

2}, Miguel Cainzos-Achirica^{1

3

4}

Affiliations

¹ Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
² Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
³ Hospital del Mar and Parc Salut Mar, Barcelona, Spain.
⁴ Barcelona Biomedical Research Park (PRBB), Barcelona, Spain.

Editorial

Marios Arvanitis et al. JACC Adv. 2022.

. 2022 Aug 26;1(3):100071.

doi: 10.1016/j.jacadv.2022.100071. eCollection 2022 Aug.

Marios Arvanitis^{1

2}, Miguel Cainzos-Achirica^{1

3

4}

¹ Division of Cardiology, Department of Medicine, Johns Hopkins University, Baltimore, Maryland, USA.
² Department of Biomedical Engineering, Johns Hopkins University, Baltimore, Maryland, USA.
³ Hospital del Mar and Parc Salut Mar, Barcelona, Spain.
⁴ Barcelona Biomedical Research Park (PRBB), Barcelona, Spain.

No abstract available

Keywords: atherosclerosis; coronary disease; familial hypercholesterolemia; polygenic risk score.

Conflict of interest statement

The authors have reported that they have no relationships relevant to the contents of this paper to disclose.

Clinical Implementation of Combined Monogenic and Polygenic Risk Disclosure for Coronary Artery Disease.
Maamari DJ, Brockman DG, Aragam K, Pelletier RC, Folkerts E, Neben CL, Okumura S, Hull LE, Philippakis AA, Natarajan P, Ellinor PT, Ng K, Zhou AY, Khera AV, Fahed AC. Maamari DJ, et al. JACC Adv. 2022 Aug;1(3):100068. doi: 10.1016/j.jacadv.2022.100068. Epub 2022 Aug 16. JACC Adv. 2022. PMID: 36147540 Free PMC article.

1. McPherson R., Tybjaerg-Hansen A. Genetics of coronary artery disease. Circ Res. 2016;118:564–578. doi: 10.1161/CIRCRESAHA.115.306566. - DOI - PubMed
1. van der Harst P., Verweij N. Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease. Circ Res. 2018;122:433–443. doi: 10.1161/CIRCRESAHA.117.312086. - DOI - PMC - PubMed
1. Elliott J., Bodinier B., Bond T.A., et al. Predictive accuracy of a polygenic risk score-enhanced prediction model vs a clinical risk score for coronary artery disease. JAMA. 2020;323:636–645. doi: 10.1001/jama.2019.22241. - DOI - PMC - PubMed
1. Lu X., Liu Z., Cui Q., et al. A polygenic risk score improves risk stratification of coronary artery disease: a large-scale prospective Chinese cohort study. Eur Heart J. 2022;43:1702–1711. doi: 10.1093/eurheartj/ehac093. - DOI - PMC - PubMed
1. Mosley J.D., Gupta D.K., Tan J., et al. Predictive accuracy of a polygenic risk score compared with a clinical risk score for incident coronary heart disease. JAMA. 2020;323:627–635. doi: 10.1001/jama.2019.21782. - DOI - PMC - PubMed