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Case Reports
. 2024 May 28;16(5):e61251.
doi: 10.7759/cureus.61251. eCollection 2024 May.

Anti-Ha Antisynthetase Syndrome: A Case Report

Vanessa P De Andrade  1 , Renata Miossi  1 , Fernando H De Souza  1 , Samuel K Shinjo  1
Affiliations
Case Reports

Anti-Ha Antisynthetase Syndrome: A Case Report

Vanessa P De Andrade et al. Cureus. .

Abstract

Anti-synthetase syndrome (ASyS) is a rare systemic autoimmune myopathy characterized by the involvement of muscles, lungs, and joints, in addition to Raynaud's phenomenon, "mechanics' hand," and fever. Laboratory ASyS is defined by the positivity of anti-aminoacyl-tRNA synthetase autoantibodies, of which anti-Jo-1 is the most common. Herein, we reported an ASyS defined by an anti-Ha autoantibody, which has rarely been described in the literature. Moreover, to the best of our knowledge, we reported the first case of anti-Ha ASyS in Brazil.

Keywords: antisythetase syndrome; autoimmune rheumatic disease; case report; inflammatory myopathy; rheumatic disease.

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Conflict of interest statement

Human subjects: Consent was obtained or waived by all participants in this study. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work.

Figures

Figure 1
Figure 1. Chest high-resolution computed tomography.
Figure 2
Figure 2. Muscle magnetic resonance imaging of the proximal part of both thighs.
Left figure: Axial T1 image. Right figure: STIR image.
See this image and copyright information in PMC

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