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Review
. 2024 Jun 28;54(3):159-169.
doi: 10.4274/tjo.galenos.2024.49779.

Tissue Engineering and Ophthalmology

Canan Aslı Utine  1   2 , Sinan Güven  2   3   4
Affiliations
Review

Tissue Engineering and Ophthalmology

Canan Aslı Utine et al. Turk J Ophthalmol. .

Abstract
in English, Turkish

Tissue engineering (TE) is a field of science that combines biological, engineering, and medical sciences and allows the development of disease models, drug development and gene therapy studies, and even cellular or tissue-based treatments developed by engineering methods. The eye is an organ that is easily accessible and amenable to engineering applications, paving the way for TE in ophthalmology. TE studies are being conducted on a wide range of topics, including the tear film, eyelids, cornea, optic nerve, glaucoma, and retinal diseases. With the rapid scientific advances in the field, it seems that TE is radically modifying the management of ocular disorders.

Doku mühendisliği (DM), biyoloji, mühendislik ve tıp bilimlerini biraraya getiren ve hastalık modellerinin geliştirilmesinden, ilaç geliştirme ve gen terapisi çalışmalarına ve hatta mühendislik yöntemleri ile geliştirilmiş hücresel veya doku temelli tedavilere imkan tanıyan bir bilim dalıdır. Gözün kolay ulaşılabilir ve mühendislik uygulamalarına yatkın bir organ oluşu, DM’nin oftalmolojideki yolunu açmıştır. Gözyaşı tabakası, göz kapağı, kornea, optik sinir, glokom ve retina hastalıklarını içeren geniş bir yelpazede DM çalışmaları yürütülmektedir. Alanındaki hızlı ilerleyen bilimsel gelişmelerle DM, oküler hastalıkların yönetimini kökten değiştiriyor gibi görünmektedir.

Keywords: Tissue engineering; disease model; drug development; gene therapy; regenerative medicine.

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Conflict of interest statement

Conflict of Interest: No conflict of interest was declared by the authors.

Figures

Figure 1
Figure 1
Schematic representation of ocular cell types and tissues. Diverse phenotypes and functions of ocular cells collectively establish and maintain vision
Figure 2
Figure 2
Pluripotent stem cells can give rise to all cell types, forming ocular cells and organoids. Ocular organoids and assembloids provide in vitro models to study the development of the eyes and related diseases. Bioengineered on-chip platforms can recapitulate physical and biochemical stimuli in a precisely controlled microenvironment, resulting in more realistic models in drug screening and personalized therapies in ophthalmology
See this image and copyright information in PMC

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