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. 2024 Aug;14(8):2277-2283.
doi: 10.1007/s13555-024-01211-2. Epub 2024 Jun 28.

Psoriasis and Sleep Disturbance: A US Population-Based Study Using the NHANES Database

Payton Smith #  1 , Joy Q Jin #  2   3 , Riley K Spencer  2 , Kareem G Elhage  2 , Chandler E Johnson  2 , Kathryn Haran  2 , Allison Kranyak  2 , Mitchell S Davis  2 , Marwa Hakimi  2 , Aric A Prather  4 , Katie L Stone  5 , Wilson Liao  2 , Tina Bhutani  2
Affiliations

Psoriasis and Sleep Disturbance: A US Population-Based Study Using the NHANES Database

Payton Smith et al. Dermatol Ther (Heidelb). 2024 Aug.

Abstract

Introduction: Psoriasis, a chronic inflammatory skin condition, affects approximately 3.0% of the US population, with patients often experiencing significant sleep disturbances. These disturbances include a higher prevalence of conditions such as obstructive sleep apnea, restless leg syndrome, and insomnia. Given the additional risks for cardiovascular disease, metabolic disorders, and depression linked to both poor sleep and psoriasis, addressing sleep issues in this patient group is critical.

Methods: The study utilized National Health and Nutrition Examination Survey (NHANES) data, focusing on individuals aged ≥ 20 years who provided information on psoriasis status and sleep. Multistage stratified survey methodology was applied, with multivariable logistic regression models used to examine the association between psoriasis and sleep issues, adjusting for factors such as age, gender, and health history.

Results: Psoriasis diagnosis was significantly associated with trouble sleeping (adjusted odds ratio [aOR] 1.88; 95% confidence interval [CI] 1.44-2.45). There was no significant association between psoriasis and sleep quantity. Older age, female gender, and a history of sleep disorders were predictors of trouble sleeping among psoriasis patients.

Conclusions: Psoriasis is significantly associated with sleep disturbances, independent of sleep duration. This underscores the need for clinical screening focusing on sleep quality rather than quantity in psoriasis patients to effectively identify and treat sleep-related comorbidities. Further research using objective sleep measures is warranted to guide clinical management and improve patient quality of life.

Keywords: Comorbidities; Dermatology; Psoriasis; Screening; Sleep quality; Sleep quantity.

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Conflict of interest statement

Joy Q. Jin has received research grant funding from the National Psoriasis Foundation and institutional funding from the University of California, San Francisco. Aric A. Prather has received research funding from Eisai and Big Health and serves as an advisor to NeuroGeneces. Wilson Liao has received research grant funding from Abbvie, Amgen, Janssen, Leo, Novartis, Pfizer, Regeneron, and TRex Bio. Tina Bhutani has received research grant funding from Novartis and Regeneron and is a principal investigator for trials sponsored by Abbvie, Castle, CorEvitas, Dermavant, Galderma, Mindera, and Pfizer. Tina Bhutani has served as an advisor for Abbvie, Arcutis, Boehringer-Ingelheim, Bristol Myers Squibb, Janssen, Leo, Lilly, Novartis, Pfizer, Sun, and UCB. The remaining authors have no conflicts of interest to disclose.

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