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Case Reports
. 2024 Jun 28;18(1):61.
doi: 10.1007/s12105-024-01665-y.

Central Myoepithelioma of the Maxilla

Carla Isabelly Rodrigues-Fernandes  1 , Danielle Machado Farias  2 , Jurema Freire Lisboa de Castro  2 , Luciano P Dos Santos  3 , Oslei Paes de Almeida  4 , Danyel Elias da Cruz Perez  2
Affiliations
Case Reports

Central Myoepithelioma of the Maxilla

Carla Isabelly Rodrigues-Fernandes et al. Head Neck Pathol. .

Abstract

Myoepithelioma is a benign salivary gland tumor. Central myoepitheliomas are very rare. The aim of this report was to describe a case of maxillary myoepithelioma. A 14-year-old female patient presented with an multilocular lesion in the anterior maxilla, with nearly 8 months of duration. The lesion was asymptomatic, and the patient's dental history was unremarkable. The diagnostic hypothesis was an odontogenic tumor. Biopsy specimen consisted of nests of plasmacytoid cells in a myxoid stroma without duct formation. No cellular atypia or bone and cartilage formation were noted. The neoplastic cells were positive for Pan-cytokeratin, S100, CK7, and CK8. The final diagnosis was myoepithelioma. The patient was treated by surgical excision followed by bone curettage, and no signs of recurrence were found after 8 years of treatment.

Keywords: Bone; Jaw; Maxilla; Myoepithelioma.

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Conflict of interest statement

The authors have no conflicts of interest to declare.

Figures

Fig. 1
Fig. 1
Radiographic features of the case. A-B: Orthopantomography of the case showing a multilocular, radiolucent image, extending from the right maxillary canine to the left maxillary canine. Dislocation of the roots of both central incisors and the lateral right incisor can be visualized
Fig. 2
Fig. 2
Microscopic and immunohistochemical features of the lesion. A: Nests of neoplastic cells with microcysts in a myxoid stroma. B-C: Monotonous infiltration of plasmacytoid cells without any atypia or pleomorphism. D: Diffuse positive cytoplasmatic staining with pan-cytokeratin, corroborating the epithelial nature of the tumor (DAB, 200x). E: Cytoplasmatic and nuclear expression of neoplastic cells for S100 was also observed (DAB, 200x). F: The tumor cells were also positive for CK7 (DAB; 400x)
See this image and copyright information in PMC

References

    1. Kurzawa P, Selig MK, Kraiński P, Dopierała M, Nielsen GP (2019) Myoepithelioma of bone: ultrastructural, immunohistochemical and molecular study of three cases. Ultrastruct Pathol 43:312–325 - PubMed
    1. Puls F, Arbajian E, Magnusson L, Douis H, Kindblom LG, Mertens F (2014) Myoepithelioma of bone with a novel FUS-POU5F1 fusion gene. Histopathology 65:917–922 - PubMed
    1. Kurzawa P, Kattapuram S, Hornicek FJ, Antonescu CR, Rosenberg AE, Nielsen GP (2013) Primary myoepithelioma of bone: a report of 8 cases. Am J Surg Pathol. :960–968 - PubMed
    1. Cuesta Gil M, Bucci T, Navarro Cuellar C, Duarte Ruiz B, Pannone G, Bufo P, Navarro Vila C (2008) Intraosseous myoepithelioma of the maxilla: clinicopathologic features and therapeutic considerations. J Oral Maxillofac Surg 66:800–803 - PubMed
    1. Ferretti C, Coleman H, Altini M, Meer S (2003) Intraosseous myoepithelial neoplasms of the maxilla: diagnostic and therapeutic considerations in 5 South African patients. J Oral Maxillofac Surg 61:379–386 - PubMed

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