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Clinical Trial
. 1985 Aug;26(8):822-4.
doi: 10.1136/gut.26.8.822.

Therapeutic benefits from a poorly absorbed prednisolone enema in distal colitis

P B McIntyre, F A Macrae, L Berghouse, J English, J E Lennard-Jones
Clinical Trial

Therapeutic benefits from a poorly absorbed prednisolone enema in distal colitis

P B McIntyre et al. Gut. 1985 Aug.

Abstract

A double blind controlled trial has been conducted in 40 patients to compare the therapeutic effects of prednisolone metasulphobenzoate enemas with those of prednisolone-21-phosphate enemas. Both enemas brought about improvement in symptoms and sigmoidoscopic appearances in more than 70% of patients treated. The absorption of prednisolone from the metasulphobenzoate enema in three patients was less than from the 21-phosphate enema. In view of the low plasma prednisolone concentrations obtained, there are theoretical advantages in using a poorly absorbed enema to avoid the possibility of systemic steroid effects in patients requiring long term steroid treatment.

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References

    1. Br Med J. 1976 Jan 24;1(6003):193-5 - PubMed
    1. Br J Clin Pharmacol. 1976 Oct;3(5):903-6 - PubMed
    1. Gut. 1979 May;20(5):349-55 - PubMed
    1. Gut. 1980 Mar;21(3):215-8 - PubMed
    1. Br Med J. 1961 Jan 21;1(5220):165-8 - PubMed