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. 2024 Jul 10;4(7):100585.
doi: 10.1016/j.xgen.2024.100585. Epub 2024 Jun 27.

Rhesus macaque as a model for sex-biased neurological diseases

Leticia Rodríguez-Montes  1 , Henrik Kaessmann  2
Affiliations

Rhesus macaque as a model for sex-biased neurological diseases

Leticia Rodríguez-Montes et al. Cell Genom. .

Abstract

Sexual dimorphism, differences between males and females of the same species, is widespread in mammals. However, good animal models to study human sexually dimorphic phenotypes are currently lacking. In this issue, DeCasien et al.1 explore the potential of rhesus macaque as a model for investigating sexually dimorphic traits in the human brain.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Figures

Figure 1
Figure 1
Sex-biased gene expression in humans compared to different animal models Transcriptomic sex differences observed in macaque resemble those found in humans, making macaque a good model to study human sex-biased neurological conditions. Created with biorender.com.
See this image and copyright information in PMC

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