Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2024 Oct;96(5):1117-1119.
doi: 10.1038/s41390-024-03370-6. Epub 2024 Jun 28.

Thioredoxin: an antioxidant, a therapeutic target and a possible biomarker

Tara Sudhadevi  1 , Anantha Harijith  2
Affiliations
Comment

Thioredoxin: an antioxidant, a therapeutic target and a possible biomarker

Tara Sudhadevi et al. Pediatr Res. 2024 Oct.
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1. Working of the thioredoxin system.
The NADPH produced by the pentose phosphate pathway donates electron to the thioredoxin (TRX) system keeping the TRX reductase (TRXR) in its reduced state, which in turn provides reducing equivalents to TRX. Reduced TRX donates electrons to several cellular proteins activating several cellular functions. Along with cellular peroxiredoxins (PRX) and ribonucleotide reductase (RNR), reduced TRX scavenges intracellular hydrogen peroxide (H2O2) and generates 2’‐deoxyribonucleotides (dNTPs) respectively. Reduced TRX also modulates the binding of transcription factors to DNA regulating gene expression. It also interacts with apoptosis signal-regulating kinase 1 (ASK1) and prevents apoptosis.
See this image and copyright information in PMC

Comment on

References

    1. Smith, C. V., Hansen, T. N., Martin, N. E., McMicken, H. W. & Elliott, S. J. Oxidant stress responses in premature infants during exposure to hyperoxia. Pediatr. Res. 34, 360–365 (1993). - PubMed
    1. Rajendran, P. et al. Antioxidants and human diseases. Clin. Chim. Acta436, 332–347 (2014). - PubMed
    1. Arnér, E. S. & Holmgren, A. Physiological functions of thioredoxin and thioredoxin reductase. Eur. J. Biochem.267, 6102–6109 (2000). - PubMed
    1. Asikainen, T. M. & White, C. W. Antioxidant defenses in the preterm lung: role for hypoxia-inducible factors in BPD? Toxicol. Appl Pharm.203, 177–188 (2005). - PubMed
    1. Lu, J. & Holmgren, A. The thioredoxin antioxidant system. Free Radic. Biol. Med.66, 75–87 (2014). - PubMed

LinkOut - more resources