Revised criteria for the diagnosis and staging of Alzheimer's disease

Clifford R Jack Jr¹, Scott J Andrews², Thomas G Beach³, Teresa Buracchio⁴, Billy Dunn⁵, Ana Graf⁶, Oskar Hansson^{7

8}, Carole Ho⁹, William Jagust¹⁰, Eric McDade¹¹, Jose Luis Molinuevo¹², Ozioma C Okonkwo¹³, Luca Pani¹⁴, Michael S Rafii¹⁵, Philip Scheltens¹⁶, Eric Siemers¹⁷, Heather M Snyder¹⁸, Reisa Sperling¹⁹, Charlotte E Teunissen²⁰, Maria C Carrillo¹⁸

Affiliations

¹ Department of Radiology, Mayo Clinic, Rochester, MN, USA. jack.clifford@mayo.edu.
² Global Evidence & Outcomes, Takeda Pharmaceuticals Company Limited, Cambridge, MA, USA.
³ Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA.
⁴ Office of Neuroscience, US Food and Drug Administration, Silver Spring, MD, USA.
⁵ The Michael J Fox Foundation for Parkinson's Research, New York, NY, USA.
⁶ Neuroscience Global Drug Development, Novartis, Basel, Switzerland.
⁷ Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.
⁸ Memory Clinic, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
⁹ Denali Therapeutics, South San Francisco, CA, USA.
¹⁰ School of Public Health and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
¹¹ Department of Neurology, Washington University St Louis School of Medicine, St Louis, MO, USA.
¹² Experimental Medicine, Department Global Clinical Development H. Lundbeck A/S, Copenhagen, Denmark.
¹³ Department of Medicine, Division of Geriatrics and Gerontology, University of Wisconsin School of Medicine, Madison, WI, USA.
¹⁴ University of Miami, Miami, FL, USA.
¹⁵ Alzheimer's Therapeutic Research Institute (ATRI), Keck School of Medicine at the University of Southern California, San Diego, CA, USA.
¹⁶ Department of Neurology, Amsterdam University Medical Center (Emeritus), Amsterdam, The Netherlands.
¹⁷ Clinical Research, Acumen Pharmaceuticals, Zionsville, IN, USA.
¹⁸ Medical & Scientific Relations Division, Alzheimer's Association, Chicago, IL, USA.
¹⁹ Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
²⁰ Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Amsterdam, The Netherlands.

PMID: 38942991
PMCID: PMC11630478
DOI: 10.1038/s41591-024-02988-7

Revised criteria for the diagnosis and staging of Alzheimer's disease

Clifford R Jack Jr et al. Nat Med. 2024 Aug.

. 2024 Aug;30(8):2121-2124.

doi: 10.1038/s41591-024-02988-7.

Authors

Affiliations

¹ Department of Radiology, Mayo Clinic, Rochester, MN, USA. jack.clifford@mayo.edu.
² Global Evidence & Outcomes, Takeda Pharmaceuticals Company Limited, Cambridge, MA, USA.
³ Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Sun City, AZ, USA.
⁴ Office of Neuroscience, US Food and Drug Administration, Silver Spring, MD, USA.
⁵ The Michael J Fox Foundation for Parkinson's Research, New York, NY, USA.
⁶ Neuroscience Global Drug Development, Novartis, Basel, Switzerland.
⁷ Clinical Memory Research Unit, Department of Clinical Sciences Malmö, Faculty of Medicine, Lund University, Lund, Sweden.
⁸ Memory Clinic, Clinical Research Centre, Skåne University Hospital, Malmö, Sweden.
⁹ Denali Therapeutics, South San Francisco, CA, USA.
¹⁰ School of Public Health and Helen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
¹¹ Department of Neurology, Washington University St Louis School of Medicine, St Louis, MO, USA.
¹² Experimental Medicine, Department Global Clinical Development H. Lundbeck A/S, Copenhagen, Denmark.
¹³ Department of Medicine, Division of Geriatrics and Gerontology, University of Wisconsin School of Medicine, Madison, WI, USA.
¹⁴ University of Miami, Miami, FL, USA.
¹⁵ Alzheimer's Therapeutic Research Institute (ATRI), Keck School of Medicine at the University of Southern California, San Diego, CA, USA.
¹⁶ Department of Neurology, Amsterdam University Medical Center (Emeritus), Amsterdam, The Netherlands.
¹⁷ Clinical Research, Acumen Pharmaceuticals, Zionsville, IN, USA.
¹⁸ Medical & Scientific Relations Division, Alzheimer's Association, Chicago, IL, USA.
¹⁹ Department of Neurology, Brigham and Women's Hospital, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
²⁰ Neurochemistry Laboratory, Department of Laboratory Medicine, Amsterdam UMC, Amsterdam, The Netherlands.

PMID: 38942991
PMCID: PMC11630478
DOI: 10.1038/s41591-024-02988-7

Abstract

Alzheimer’s disease can be treated by targeting amyloid-β plaques and diagnosed in vivo by biomarkers, prompting the revision of criteria for the diagnosis and staging of this disease.

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References

1. Jack CR Jr., Andrews S, Beach T, et al. Revised Criteria for Diagnosis and Staging of Alzheimer’s Disease: Alzheimer’s Alzheimer’s dement 2024;accepted for publication. - PMC - PubMed
1. Sperling RA, Aisen PS, Beckett LA, et al. Toward defining the preclinical stages of Alzheimer’s disease: recommendations from the National Institute on Aging-Alzheimer’s Assocation workgroups on diagnostic guidelines for Alzheimer’s disease. Alzheimers Dement 2011;7:280–292. - PMC - PubMed
1. Jack CR Jr., Bennett DA, Blennow K, et al. NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease. Alzheimers Dement 2018;14:535–562. - PMC - PubMed
1. van Dyck CH, Swanson CJ, Aisen P, et al. Lecanemab in Early Alzheimer’s Disease. N Engl J Med 2023;388:9–21. - PubMed
1. Sims JR, Zimmer JA, Evans CD, et al. Donanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial. JAMA 2023;330:512–527. - PMC - PubMed

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Revised criteria for the diagnosis and staging of Alzheimer's disease

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Revised criteria for the diagnosis and staging of Alzheimer's disease

Authors

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Abstract

References

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Medical