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Review
. 2024 Jun 28;41(3):2024-vol3.
doi: 10.69097/41-03-2024-03.

[HIF-ɑ: New Target For Treatment of Renal Anemia. Molecular Aspects and Activation of Pathway HREs]

[Article in Italian]
Fabio Mazza  1 , Angela Cicciarelli  1 , Filomena Rubino  1 , Francesca Apponi  2 , Ernesto Anselmo Cioffi  1 , Roberto Simonelli  3
Affiliations
Review

[HIF-ɑ: New Target For Treatment of Renal Anemia. Molecular Aspects and Activation of Pathway HREs]

[Article in Italian]
Fabio Mazza et al. G Ital Nefrol. .

Abstract

Roxadustat, recently approved, is a hypoxia-inducible factor prolyl hydroxylase inhibitor that has demonstrated favorable safety and efficacy in the treatment of renal anemia. This article reviews main features and possible effects by activation of pathway sequences HREs.

Keywords: EPO; Roxadustat; hypoxia-inducible factor; inflammation; oxidative stress.

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