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Review
. 2024 Aug;71(1):151-167.
doi: 10.1016/j.yapd.2024.04.002. Epub 2024 May 4.

Novel Approaches to Patients with Differences of Sex Development

Brielle Ochoa  1 , Erica M Weidler  1 , Melissa A Parks  2 , Karen Elizabeth Speck  3 , Kathleen van Leeuwen  4
Affiliations
Review

Novel Approaches to Patients with Differences of Sex Development

Brielle Ochoa et al. Adv Pediatr. 2024 Aug.

Abstract

Patients with differences of sex development (DSDs) have complex anatomy and surgical needs related to both Mullerian and non-Mullerian structures. Approaches to vaginal reconstruction for these conditions are guided by individual anatomy, with the goal of establishing unobstructed outflow for the reproductive, urinary, and gastrointestinal tracts. Patients may have anatomy requiring vaginoplasty for either outflow tract obstruction or chosen sexual function. In this article, the authors focus on management of differences in vaginal anatomy with delayed vaginoplasty for the newborn with DSD.

Keywords: Differences of sex development (DSDs); Mullerian anomaly; Outflow tract obstruction (OTO); Reconstruction; Shared decision-making; Vaginoplasty.

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Conflict of interest statement

Disclosure The authors have no commercial or financial interests to disclose. The authors did not receive funding in relation to this article but the longitudinal work was supported by grants from the Eunice Kennedy Shriver National Institute for Child Health and Human Development (R01 HD086583 and R01 HD093450).

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