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Review
. 2024 Aug;71(1):213-228.
doi: 10.1016/j.yapd.2024.02.001. Epub 2024 Mar 21.

Overview of Systemic Autoinflammatory Diseases

Samira Nazzar Romero  1 , Deborah McCurdy  2
Affiliations
Review

Overview of Systemic Autoinflammatory Diseases

Samira Nazzar Romero et al. Adv Pediatr. 2024 Aug.

Abstract

Systemic autoinflammatory diseases (SAID) are a growing family of disorders of the innate immune system. Over the years, there have been changes in the definition, classification and nomenclature of SAID as new syndromes and pathophysiologic mechanisms continue to be described. Recognizing the clinical manifestations of SAID is important for their early diagnosis and management. The field continues to advance with potential new therapies underway.

Keywords: Autoinflammation; Autoinflammatory diseases; Inflammasome; Interferonopathy; NF-κB; Periodic fevers; Recurrent fevers; Tumor necrosis factor.

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Conflict of interest statement

Disclosure There was no financial support, grants or benefits from commercial sources utilized for the elaboration of this article. S. Nazzar Romero with Aurinia pharmaceuticals. D. McCurdy has no disclosures.

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