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. 2024 Jul 1;14(7):1143-1144.
doi: 10.1158/2159-8290.CD-24-0539.

Pan-RAF:MEK Molecular Glues Take Center Stage

Matthew J Hangauer  1   2 , Jorge Silvio Gutkind  3   2 , Fleur M Ferguson  2   4   5
Affiliations

Pan-RAF:MEK Molecular Glues Take Center Stage

Matthew J Hangauer et al. Cancer Discov. .

Abstract

In this issue, Ryan and colleagues describe the preclinical development of a pan-RAF:MEK molecular glue with superior efficacy, brain penetrance, and tolerability in xenograft models of Ras/Raf/MAPK pathway-driven tumors. See related article by Ryan et al., p. 1190 (1).

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