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Review
. 2024 Jun 14;30(22):2852-2865.
doi: 10.3748/wjg.v30.i22.2852.

Enteric neuropathy in diabetes: Implications for gastrointestinal function

Mona Mohamed Ibrahim Abdalla  1
Affiliations
Review

Enteric neuropathy in diabetes: Implications for gastrointestinal function

Mona Mohamed Ibrahim Abdalla. World J Gastroenterol. .

Abstract

Diabetes, commonly known for its metabolic effects, also critically affects the enteric nervous system (ENS), which is essential in regulating gastrointestinal (GI) motility, secretion, and absorption. The development of diabetes-induced enteric neuropathy can lead to various GI dysfunctions, such as gastroparesis and irregular bowel habits, primarily due to disruptions in the function of neuronal and glial cells within the ENS, as well as oxidative stress and inflammation. This editorial explores the pathophysiological mechanisms underlying the development of enteric neuropathy in diabetic patients. Additionally, it discusses the latest advances in diagnostic approaches, emphasizing the need for early detection and intervention to mitigate GI complications in diabetic individuals. The editorial also reviews current and emerging therapeutic strategies, focusing on pharmacological treatments, dietary management, and potential neuromodulatory interventions. Ultimately, this editorial highlights the necessity of a multidisciplinary approach in managing enteric neuropathy in diabetes, aiming to enhance patient quality of life and address a frequently overlooked complication of this widespread disease.

Keywords: Diabetes; Diabetic neuropathy; Enteric nervous system; Enteric neuropathy; Gastrointestinal; Insulin resistance.

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Conflict of interest statement

Conflict-of-interest statement: The author declares no conflict of interest for this article.

Figures

Figure 1
Figure 1
Mechanisms of diabetic enteric neuropathy. AGEs: Advanced glycation end-products.
Figure 2
Figure 2
Impact of diabetic enteric neuropathy on gastrointestinal tract. GERD: Gastroesophageal reflux disease.
See this image and copyright information in PMC

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