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. 2024 Jun 30;6(3):190-198.
doi: 10.35772/ghm.2023.01113.

Low preoperative hemoglobin A1c level is a predictor of perioperative infectious complications after esophagectomy: A retrospective, single-center study

Daiki Kato  1   2 , Kazuhiko Yamada  1   2 , Naoki Enomoto  1 , Syusuke Yagi  1 , Hanako Koda  1 , Kyoko Nohara  1
Affiliations

Low preoperative hemoglobin A1c level is a predictor of perioperative infectious complications after esophagectomy: A retrospective, single-center study

Daiki Kato et al. Glob Health Med. .

Abstract

This retrospective, single-center study aimed to evaluate the impact of blood glucose (BG) markers on perioperative complications after esophagectomy in a cohort of 176 patients. Study analyses included the correlation of daily maximum BG level and hemoglobin A1c (HbA1c) with clinicopathological factors. Maximum BG levels were significantly higher on postoperative day (POD) 0 than on PODs 2, 3, 5, and 7 (p < 0.05). Additionally, maximum BG levels on PODs 1, 2, and 7 were significantly higher in patients with preoperative HbA1c levels of ≥ 5.6% than in those with preoperative HbA1c levels of < 5.6% (p < 0.05 for all). The rates of any complications and infectious complications were higher in patients with preoperative HbA1c levels of < 5.6% than in those with preoperative HbA1c levels of ≥ 5.6% (p < 0.05 for both). A preoperative HbA1c level of < 5.6% was a significant predictor of infectious complications after esophagectomy by logistic regression analysis (p < 0.05). Maximum BG level after esophagectomy remained high in patients with high preoperative HbA1c levels, whereas a normal HbA1c level was an independent risk factor for infectious complications.

Keywords: HbA1c; blood glucose; esophageal surgery; postoperative hyperglycemia.

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Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
Inclusion criteria.
Figure 2.
Figure 2.
Changes in maximum blood glucose levels after esophagectomy from postoperative day 0 to 7 mBGL, maximum blood glucose level; POD, postoperative day. *p < 0.05 by Mann-Whitney U test.
See this image and copyright information in PMC

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