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Review
. 2024 Jan-Dec;16(1):2360233.
doi: 10.1080/19490976.2024.2360233. Epub 2024 Jul 1.

The gut microbiome in disorders of gut-brain interaction

Narjis Kraimi  1 , Taylor Ross  1 , Julien Pujo  1 , Giada De Palma  1
Affiliations
Review

The gut microbiome in disorders of gut-brain interaction

Narjis Kraimi et al. Gut Microbes. 2024 Jan-Dec.

Abstract

Functional gastrointestinal disorders (FGIDs), chronic disorders characterized by either abdominal pain, altered intestinal motility, or their combination, have a worldwide prevalence of more than 40% and impose a high socioeconomic burden with a significant decline in quality of life. Recently, FGIDs have been reclassified as disorders of gut-brain interaction (DGBI), reflecting the key role of the gut-brain bidirectional communication in these disorders and their impact on psychological comorbidities. Although, during the past decades, the field of DGBIs has advanced significantly, the molecular mechanisms underlying DGBIs pathogenesis and pathophysiology, and the role of the gut microbiome in these processes are not fully understood. This review aims to discuss the latest body of literature on the complex microbiota-gut-brain interactions and their implications in the pathogenesis of DGBIs. A better understanding of the existing communication pathways between the gut microbiome and the brain holds promise in developing effective therapeutic interventions for DGBIs.

Keywords: Microbiome; abdominal pain; disorders of gut–brain interaction; functional dyspepsia; gut function; irritable bowel syndrome; microbial metabolome; visceral hypersensitivity.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
The role of microbiome in disorders of gut brain interaction (DGBI).
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