Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer
- PMID: 38951029
- PMCID: PMC11875093
- DOI: 10.1101/cshperspect.a041548
Interactions of Fatty Acid and Cholesterol Metabolism with Cellular Stress Response Pathways in Cancer
Abstract
Lipids have essential functions as structural components of cellular membranes, as efficient energy storage molecules, and as precursors of signaling mediators. While deregulated glucose and amino acid metabolism in cancer have received substantial attention, the roles of lipids in the metabolic reprogramming of cancer cells are less well understood. However, since the first description of de novo fatty acid biosynthesis in cancer tissues almost 70 years ago, numerous studies have investigated the complex functions of altered lipid metabolism in cancer. Here, we will summarize the mechanisms by which oncogenic signaling pathways regulate fatty acid and cholesterol metabolism to drive rapid proliferation and protect cancer cells from environmental stress. The review also discusses the role of fatty acid metabolism in metabolic plasticity required for the adaptation to changing microenvironments during cancer progression and the connections between fatty acid and cholesterol metabolism and ferroptosis.
Copyright © 2025 Cold Spring Harbor Laboratory Press; all rights reserved.
Similar articles
-
Greasing the Wheels of the Cancer Machine: The Role of Lipid Metabolism in Cancer.Cell Metab. 2020 Jan 7;31(1):62-76. doi: 10.1016/j.cmet.2019.11.010. Epub 2019 Dec 5. Cell Metab. 2020. PMID: 31813823 Review.
-
Reprogramming of fatty acid metabolism in cancer.Br J Cancer. 2020 Jan;122(1):4-22. doi: 10.1038/s41416-019-0650-z. Epub 2019 Dec 10. Br J Cancer. 2020. PMID: 31819192 Free PMC article. Review.
-
p53 regulates lipid metabolism in cancer.Int J Biol Macromol. 2021 Dec 1;192:45-54. doi: 10.1016/j.ijbiomac.2021.09.188. Epub 2021 Oct 5. Int J Biol Macromol. 2021. PMID: 34619274 Review.
-
Even Cancer Cells Watch Their Cholesterol!Mol Cell. 2019 Oct 17;76(2):220-231. doi: 10.1016/j.molcel.2019.09.008. Epub 2019 Oct 2. Mol Cell. 2019. PMID: 31586545 Free PMC article. Review.
-
Lipid metabolism in dendritic cell biology.Immunol Rev. 2023 Aug;317(1):137-151. doi: 10.1111/imr.13215. Epub 2023 May 12. Immunol Rev. 2023. PMID: 37172120 Free PMC article. Review.
Cited by
-
Molecular Imprints of Clinical Comorbidities in Hypothalamic Extracellular Vesicles at the Onset of Obesity.ACS Omega. 2025 May 29;10(22):23563-23581. doi: 10.1021/acsomega.5c02274. eCollection 2025 Jun 10. ACS Omega. 2025. PMID: 40521556 Free PMC article.
References
-
- Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, et al. 2023. A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-κB signaling. Nat Cancer 4: 344–364. 10.1038/s43018-023-00513-2 - DOI - PMC - PubMed
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical