Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2024 Sep;310(3):1525-1534.
doi: 10.1007/s00404-024-07604-0. Epub 2024 Jul 1.

Obstetric and perinatal outcomes of women with a history of recurrent pregnancy loss: a meta-analysis of cohort studies

Junxiu Liu  1 , Mingyang Zhao  1 , Jia Zhuan  1 , Yanmin Song  1 , Zhe Han  1 , Yuanyuan Zhao  1 , Hua Ma  1 , Xiumei Yang  2
Affiliations
Meta-Analysis

Obstetric and perinatal outcomes of women with a history of recurrent pregnancy loss: a meta-analysis of cohort studies

Junxiu Liu et al. Arch Gynecol Obstet. 2024 Sep.

Abstract

Purpose: To assess the risk of adverse obstetric and perinatal outcomes in subsequent pregnancies among women with a history of recurrent pregnancy loss (RPL).

Methods: Relevant studies were identified by searching the PubMed, Web of Science, and Embase databases. The pooled effect sizes were reported as odds ratios (OR) with their respective 95% confidence intervals (95% CI), and data analysis was performed using the random effects model.

Results: A total of 26 studies involving 4,730,728 women were included in this meta-analysis. The results reveal a significant increase in the prevalence of placenta accreta cases after RPL compared to women without RPL (pooled OR 4.04; 95% CI 1.16-14.15; 2 studies; I2 = 94%; P = 0.03). However, no elevated risk of aneuploidies (pooled OR 1.69, 95% CI 0.73-3.90; 5 studies; I2 = 48%; P = 0.22) or congenital anomalies (pooled OR 1.12, 95% CI 0.97-1.30; 7 studies; I2 = 13%; P = 0.12) in subsequent pregnancies of women with RPL was observed. Additionally, a moderate increase in the risk of various other obstetric and perinatal outcomes was found. The magnitude of the elevated risk of these adverse outcomes varied depending on the region.

Conclusions: Women with a history of RPL exhibit a significantly elevated risk of placenta accreta in subsequent pregnancies, along with a moderate increase in the risk of various other adverse obstetric and perinatal outcomes. However, RPL does not signify an increased risk of aneuploidies or congenital anomalies in a consecutive pregnancy.

Keywords: Cohort studies; Meta-analysis; Obstetric and perinatal outcomes; Recurrent pregnancy loss.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Practice committee of the American society for reproductive medicine and others (2012) Evaluation and treatment of recurrent pregnancy loss: a committee opinion. Fertil Steril 98(5):1103–1111. https://doi.org/10.1016/j.fertnstert.2012.06.048 - DOI
    1. Magnus MC, Wilcox AJ, Morken NH, Weinberg CR, Håberg SE (2019) Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study. BMJ 364:1869. https://doi.org/10.1136/bmj.1869 - DOI
    1. Linnakaari R, Helle N, Mentula M, Bloigu A, Gissler M, Heikinheimo O et al (2019) Trends in the incidence, rate and treatment of miscarriage-nationwide register-study in Finland, 1998–2016. Hum Reprod 34(11):2120–2128. https://doi.org/10.1093/humrep/dez211 - DOI - PubMed
    1. Li TC, Makris M, Tomsu M, Tuckerman E, Laird S (2002) Recurrent miscarriage: aetiology, management and prognosis. Hum Reprod Update 8(5):463–481. https://doi.org/10.1093/humupd/8.5.463 - DOI - PubMed
    1. Giouleka S, Tsakiridis I, Arsenaki E, Kalogiannidis I, Mamopoulos A, Papanikolaou E et al (2023) Investigation and management of recurrent pregnancy loss: a comprehensive review of guidelines. Obstet Gynecol Surv 78(5):287–301. https://doi.org/10.1097/OGX.0000000000001133 - DOI - PubMed

Publication types

LinkOut - more resources