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Review
. 2024 Aug;34(8):3071-3083.
doi: 10.1007/s11695-024-07378-z. Epub 2024 Jul 1.

The Potential Mechanism of Remission in Type 2 Diabetes Mellitus After Vertical Sleeve Gastrectomy

Rongfei Wang #  1 , Salamu Mijiti #  2 , Qilin Xu #  2 , Yile Liu  1 , Chaolun Deng  1 , Jiangtao Huang  1 , Abudoukeyimu Yasheng  2 , Yunping Tian  3 , Yanlong Cao  4 , Yonghui Su  5
Affiliations
Review

The Potential Mechanism of Remission in Type 2 Diabetes Mellitus After Vertical Sleeve Gastrectomy

Rongfei Wang et al. Obes Surg. 2024 Aug.

Abstract

In recent years, there has been a gradual increase in the prevalence of obesity and type 2 diabetes mellitus (T2DM), with bariatric surgery remaining the most effective treatment strategy for these conditions. Vertical sleeve gastrectomy (VSG) has emerged as the most popular surgical procedure for bariatric/metabolic surgeries, effectively promoting weight loss and improving or curing T2DM. The alterations in the gastrointestinal tract following VSG may improve insulin secretion and resistance by increasing incretin secretion (especially GLP-1), modifying the gut microbiota composition, and through mechanisms dependent on weight loss. This review focuses on the potential mechanisms through which the enhanced action of incretin and metabolic changes in the digestive system after VSG may contribute to the remission of T2DM.

Keywords: Gut microbiota; Incretin effect; Type 2 diabetes mellitus (T2DM); Vertical sleeve gastrectomy (VSG).

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